EFFECTS OF VALERIANA OFFICINAL IS EXTRACT ON THE SEIZURE INDUCED BY PICROTOXIN IN MICE

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HEIDARI M.R.; RAZBAN FARIDEH

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

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Journal: Journal of Kerman University of Medical Sciences Year:2004 | Volume:11 | Issue:2 Page(s): 100-108

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Title

EFFECTS OF VALERIANA OFFICINAL IS EXTRACT ON THE SEIZURE INDUCED BY PICROTOXIN IN MICE

Author(s)

HEIDARI M.R. | RAZBAN FARIDEH | Issue Writer Certificate

Keywords

VALERIANA OFFICINAL ISQ3

SEIZUREQ3

PICROTOXINQ4

MICE JOURNAL OF KERMAN UNIVERSITY OF MEDICALQ2

Abstract

Neurological effects of VALERIANA OFFICINAL IS having been recognized for many years. In this study, the anticonvulsant activity of methanolie extract of the plant were investigated in mice PICROTOXIN with doses of 6 and 12.5 mg/kg were used for induction of SEIZUREs. The effects of different doses of methanolic extract of the plant on the variation of beginning time of SEIZUREs, the incidence of tonic and clonic SEIZUREs and mortality rate were determined. The beginning time of tonic SEIZUREs induced by PICROTOXIN (6 & 12.5 mg/kg I.P.) were delayed significantly in group which received extract (50 mg/kg I.P.) 20 min. before PICROTOXIN administration. Latency of beginning time of tonic SEIZUREs in mice which receive PICROTOXIN 6mg/kg were increased significantly from 10.58 min to 15 min (P<0.05) and in case of 12mg/kg of PICROTOXIN from 5.87 to 10.82 min.(P<0.01). The incidence of clonic SEIZUREs and mortality rate were decreased in this group of animals (P<0.05, P<0.01). The results indicated that valerian extract may be effective on generalized tonic, cloinc and tonic - clonic SEIZUREs and the dose of 50 mg/kg was enough to produce effective concentration for anticonvulsive activity of the extract in mice.

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References

EXPERIMENTAL STUDY TO EVALUATE THE PRETREATMENT OF MELISSA OFFICINALIS EXTRACT AGAINST LETHAL SEIZURES INDUCED BY PENTYLENTETRAZOLE IN WISTAR RATS

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APA: Copy

HEIDARI, M.R., & RAZBAN, FARIDEH. (2004). EFFECTS OF VALERIANA OFFICINAL IS EXTRACT ON THE SEIZURE INDUCED BY PICROTOXIN IN MICE. JOURNAL OF KERMAN UNIVERSITY OF MEDICAL SCIENCES, 11(2), 100-108. SID. https://sid.ir/paper/151/en

Vancouver: Copy

HEIDARI M.R., RAZBAN FARIDEH. EFFECTS OF VALERIANA OFFICINAL IS EXTRACT ON THE SEIZURE INDUCED BY PICROTOXIN IN MICE. JOURNAL OF KERMAN UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2004;11(2):100-108. Available from: https://sid.ir/paper/151/en

IEEE: Copy

M.R. HEIDARI, and FARIDEH RAZBAN, “EFFECTS OF VALERIANA OFFICINAL IS EXTRACT ON THE SEIZURE INDUCED BY PICROTOXIN IN MICE,” JOURNAL OF KERMAN UNIVERSITY OF MEDICAL SCIENCES, vol. 11, no. 2, pp. 100–108, 2004, [Online]. Available: https://sid.ir/paper/151/en

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