THE ROLE OF GLYCOCONJUGATES IN DEVELOPMENT OF FLOOR PLATE DURING EARLY MORPHOGENESIS IN MOUSE EMBRYO

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HASANZADEH TAHERI M.M.; NIKRAVESH M.R.; JALALI M.; FAZEL A.R.

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Journal: Journal of Kerman University of Medical Sciences Year:2004 | Volume:11 | Issue:2 Page(s): 85-93

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Title

THE ROLE OF GLYCOCONJUGATES IN DEVELOPMENT OF FLOOR PLATE DURING EARLY MORPHOGENESIS IN MOUSE EMBRYO

Author(s)

HASANZADEH TAHERI M.M. | NIKRAVESH M.R. | JALALI M. | FAZEL A.R. | Issue Writer Certificate

Keywords

GLYCOCONJUGATEQ3

NOTOCHORDQ4

FLOOR PLATEQ4

INTERACTIONQ4

EMBRYOGENESISQ4

Abstract

The FLOOR PLATE is a small group of cells located at the ventral midline of neural tube. During early neurogenesis the FLOOR PLATE plays critical role (s) in differentiation of ventral portion of neural tube. The purpose of this study was to determine the distribution of GLYCOCONJUGATEs in FLOOR PLATE as well as underlying mesoderm (notochord) and their inductive activities in mouse embryos. Formalin fixed sections embedded in paraffin from 10 to 14 days old Balb/C mouse embryos were processed for histochemical studies by using five different horseradish peroxidase (HRP) labeled lectins including; Glycin max (SBA) specific for Gal and GalNac terminal sugar, Vicia Villosa (VVA) and Arachis hypogaea (peanut) for GalNac, Ulex europeus (UEA-1) and Lotus tetragonolobus (LTA) for α- L-fucose. Our results showed that SBA sensitive glycocorifugates react and change in FLOOR PLATE, NOTOCHORDal cells and surrounding extracellular matrix and these changes were significant (P<0.05). Extensive differences between GalNac sensitive lectins were observed during motoneuron differentiation. There was no reaction with other tested GalNac lectins. Furthermore we observed significant changes (P<0.05) infucose glycocorifugates during NOTOCHORDal development. The results suggest that the timing and distribution of SBA sensitive glycocorifugates may play α key role (s) in INTERACTIONs and subsequent formation of atijacent tissues such as FLOOR PLATE and NOTOCHORD during critical period of morphogenesis. Our finding also showed that GLYCOCONJUGATEs with fucose terminal sugar may play α role (s) in NOTOCHORDal development but probably have no function on FLOOR PLATE development.

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APA: Copy

HASANZADEH TAHERI, M.M., NIKRAVESH, M.R., JALALI, M., & FAZEL, A.R.. (2004). THE ROLE OF GLYCOCONJUGATES IN DEVELOPMENT OF FLOOR PLATE DURING EARLY MORPHOGENESIS IN MOUSE EMBRYO. JOURNAL OF KERMAN UNIVERSITY OF MEDICAL SCIENCES, 11(2), 85-93. SID. https://sid.ir/paper/152/en

Vancouver: Copy

HASANZADEH TAHERI M.M., NIKRAVESH M.R., JALALI M., FAZEL A.R.. THE ROLE OF GLYCOCONJUGATES IN DEVELOPMENT OF FLOOR PLATE DURING EARLY MORPHOGENESIS IN MOUSE EMBRYO. JOURNAL OF KERMAN UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2004;11(2):85-93. Available from: https://sid.ir/paper/152/en

IEEE: Copy

M.M. HASANZADEH TAHERI, M.R. NIKRAVESH, M. JALALI, and A.R. FAZEL, “THE ROLE OF GLYCOCONJUGATES IN DEVELOPMENT OF FLOOR PLATE DURING EARLY MORPHOGENESIS IN MOUSE EMBRYO,” JOURNAL OF KERMAN UNIVERSITY OF MEDICAL SCIENCES, vol. 11, no. 2, pp. 85–93, 2004, [Online]. Available: https://sid.ir/paper/152/en

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