EFFECT OF GROWTH HORMONE ON HISTOMORPHOMETERICAL PARAMETERS OF TESTIS AFTER METHOTREXATE ADMINISTRATION IN RAT

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SAFAVI S.E.; KHAYAT NOURI M.H.; KHAKI A.; SERATI NOURI H.

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Journal: JOURNAL OF VETERINARY MICROBIOLOGY Year:2010 | Volume:6 | Issue:1 (19) Page(s): 23-29

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Title

EFFECT OF GROWTH HORMONE ON HISTOMORPHOMETERICAL PARAMETERS OF TESTIS AFTER METHOTREXATE ADMINISTRATION IN RAT

Author(s)

SAFAVI S.E. | KHAYAT NOURI M.H. | KHAKI A. | SERATI NOURI H. | Issue Writer Certificate

Keywords

HISTOMORPHOMETERYQ2

GROWTH HORMONEQ2

METHOTREXATEQ2

TESTISQ2

RATQ2

Abstract

Methotrexate (MTX) is a chemotherapeutic agent that used for the treatment of a variety of tumors and inflammatory diseases. The aim of this study was investigated the effect of GROWTH HORMONE on histomorphometerical parameters of TESTIS after METHOTREXATE administration in RAT. In this experimental study, the eighty male wistar RAT were selected and randomly divided into eight groups; control (n=20) and test (n=60). One and two test groups were received 0.3 mg/kg GH (IP) for 14 and 28 consequence days, respectively. Three and four test groups were received 1mg/kg MTX (IP) per week for 14 and 28 consequence days, respectively. Five and six test groups were received 1mg/kg MTX (IP) with 0.3mg/kg GH (IP) (MTX+GH) for 14 and 28 consequence days, respectively. However the one and two control groups just received normal saline (IP) for 14 and 28 consequence days, respectively. In 14 and 28 day, ten RATs from each group were sacrificed and the TESTIS was sampled after passing of above times and section providing, and was stained by H& E technique. Then, histologically and histomorphometerically parameters include: diameter of seminiferous tubules, thickness of epithelium of seminiferous tubules, thickness of interstitial tissue, and thickness of testicular capsule, were studied. Results of this study showed that METHOTREXATE had destructive effects on TESTIS tissue and spermatogenesis in test group compared with control group. Also, results showed that in 28 day after METHOTREXATE administration diameter of seminiferous tubules and thickness of epithelium of seminiferous tubules significantly decreased (p<0.05), but thickness of interstitial tissue and thickness of testicular capsule significantly increased (p<0.05) compared with control group. GH administration had non significant effect on TESTIS HISTOMORPHOMETERY. In GH+MTX group, GH caused significantly (p<0.05) amelioration effects on TESTIS HISTOMORPHOMETERY and spermatogenesis compared with MTX group. Although the effect of METHOTREXATE on spermatogenesis and unfertilization in human needs to be more investigation.

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APA: Copy

SAFAVI, S.E., KHAYAT NOURI, M.H., KHAKI, A., & SERATI NOURI, H.. (2010). EFFECT OF GROWTH HORMONE ON HISTOMORPHOMETERICAL PARAMETERS OF TESTIS AFTER METHOTREXATE ADMINISTRATION IN RAT. JOURNAL OF VETERINARY MICROBIOLOGY, 6(1 (19)), 23-29. SID. https://sid.ir/paper/152015/en

Vancouver: Copy

SAFAVI S.E., KHAYAT NOURI M.H., KHAKI A., SERATI NOURI H.. EFFECT OF GROWTH HORMONE ON HISTOMORPHOMETERICAL PARAMETERS OF TESTIS AFTER METHOTREXATE ADMINISTRATION IN RAT. JOURNAL OF VETERINARY MICROBIOLOGY[Internet]. 2010;6(1 (19)):23-29. Available from: https://sid.ir/paper/152015/en

IEEE: Copy

S.E. SAFAVI, M.H. KHAYAT NOURI, A. KHAKI, and H. SERATI NOURI, “EFFECT OF GROWTH HORMONE ON HISTOMORPHOMETERICAL PARAMETERS OF TESTIS AFTER METHOTREXATE ADMINISTRATION IN RAT,” JOURNAL OF VETERINARY MICROBIOLOGY, vol. 6, no. 1 (19), pp. 23–29, 2010, [Online]. Available: https://sid.ir/paper/152015/en

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