STUDY ON THE INJECTION OF GHRELIN ON THE SERUM UREA AND CREATININE CONCENTRATION IN RATS EXPOSED TO ENDOTOXEMIA CONDITION

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CHERAGHI J.; VAEZI GH.; ABDOLLAHI POOR E.

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Journal: JOURNAL OF VETERINARY MICROBIOLOGY Year:2010 | Volume:6 | Issue:1 (19) Page(s): 37-43

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Title

STUDY ON THE INJECTION OF GHRELIN ON THE SERUM UREA AND CREATININE CONCENTRATION IN RATS EXPOSED TO ENDOTOXEMIA CONDITION

Author(s)

CHERAGHI J. | VAEZI GH. | ABDOLLAHI POOR E. | Issue Writer Certificate

Keywords

GHRELINQ2

UREAQ2

CREATININEQ3

ENDOTOXEMIAQ2

RATQ2

Abstract

In this research it is mostly paid attention to the effect of physiologicaly GHRELIN and the role of GHRELIN in renal function which is the result of bacterial lipopolysaccharids (LPS) in RATs. The number of 70 RATs which have divided in 7 group for the experiment. firstly RATs were IP injection of (LPS) by the amount of 20mg/kg B.W induced ENDOTOXEMIA effects. Moreover GHRELIN by the amount of 4nmol befor and after the injection of LPS which is done by injection IP method. The result clearly illustrate that injection of GHRELIN could prevention the effects of LPS in renal function. In fact, with compared that of indicator group, the injection of two dose GHRELIN befor and after the injection of LPS leads to the deacrese significantly in the serum CREATININE concentration and also the injection of one dose GHRELIN before and 5 dose after the injection of LPS due to the reduce considerably in the serum UREA concentration (P<0.05). It would appear from the result that treatment with GHRELIN could correct the abnormalities of situation renal nephrotoxicity in ENDOTOXEMIA with reduce the level of UREA and CREATININE concentration in blood serum.

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References

NITRIC OXIDE SYNTHASE INHIBITOR INCREASES HEPATIC INJURY WITH FORMATION OF OXIDATIVE DNA DAMAGE AND MICROCIRCULATORY DISTURBANCE IN ENDOTOXEMIA RAT

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APA: Copy

CHERAGHI, J., VAEZI, GH., & ABDOLLAHI POOR, E.. (2010). STUDY ON THE INJECTION OF GHRELIN ON THE SERUM UREA AND CREATININE CONCENTRATION IN RATS EXPOSED TO ENDOTOXEMIA CONDITION. JOURNAL OF VETERINARY MICROBIOLOGY, 6(1 (19)), 37-43. SID. https://sid.ir/paper/152026/en

Vancouver: Copy

CHERAGHI J., VAEZI GH., ABDOLLAHI POOR E.. STUDY ON THE INJECTION OF GHRELIN ON THE SERUM UREA AND CREATININE CONCENTRATION IN RATS EXPOSED TO ENDOTOXEMIA CONDITION. JOURNAL OF VETERINARY MICROBIOLOGY[Internet]. 2010;6(1 (19)):37-43. Available from: https://sid.ir/paper/152026/en

IEEE: Copy

J. CHERAGHI, GH. VAEZI, and E. ABDOLLAHI POOR, “STUDY ON THE INJECTION OF GHRELIN ON THE SERUM UREA AND CREATININE CONCENTRATION IN RATS EXPOSED TO ENDOTOXEMIA CONDITION,” JOURNAL OF VETERINARY MICROBIOLOGY, vol. 6, no. 1 (19), pp. 37–43, 2010, [Online]. Available: https://sid.ir/paper/152026/en

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