EFFECT OF VALERIAN OFFICINALIS ROOT EXTRACT ON PTZ- INDUCED SEIZURE THRESHOLD IN MICE

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KHAYAT NOURI M.H.; NAMVARAN A.

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Journal: JOURNAL OF VETERINARY MICROBIOLOGY Year:2011 | Volume:7 | Issue:21 (SUPPLEMENTARY) Page(s): 43-47

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Title

EFFECT OF VALERIAN OFFICINALIS ROOT EXTRACT ON PTZ- INDUCED SEIZURE THRESHOLD IN MICE

Author(s)

KHAYAT NOURI M.H. | NAMVARAN A. | Issue Writer Certificate

Keywords

VALERIAN OFFICINALISQ2

PTZQ2

SEIZUREQ2

MICEQ2

Abstract

Different studies showed that the root of VALERIAN OFFICINALIScontains free amino acid like GABA and other material like Valeric acid and Isovalerat. Also showed that GABA, Valeric acid and Isovalerat had anticonvulsant effects in animal SEIZURE models. In traditional medicine anticonvulsant effect of VALERIAN OFFICINALISis reminded. In this study anticonvulsant effect of VALERIAN OFFICINALIS using standard method of making chemical SEIZURE with PTZ in MICE, was studied. After measuring SEIZURE threshold with PTZ in control group, different doses of VALERIAN OFFICINALIS (0.25, 0.5, 1 g/kg) orally administrated. Results showed that the PTZ SEIZURE threshold was 35.52 0.85 mg/kg in control group. In animals pretreated with VALERIAN OFFICINALIS the PTZ SEIZURE threshold showed dose dependently increased (p<0.05). In conclusion results showed that: the mechanism of anticonvulsant effect of VALERIAN OFFICINALIS probably is via GABAergic effect of this agent. This subject needs to be more investigation in human.

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APA: Copy

KHAYAT NOURI, M.H., & NAMVARAN, A.. (2011). EFFECT OF VALERIAN OFFICINALIS ROOT EXTRACT ON PTZ- INDUCED SEIZURE THRESHOLD IN MICE. JOURNAL OF VETERINARY MICROBIOLOGY, 7(21 (SUPPLEMENTARY)), 43-47. SID. https://sid.ir/paper/152126/en

Vancouver: Copy

KHAYAT NOURI M.H., NAMVARAN A.. EFFECT OF VALERIAN OFFICINALIS ROOT EXTRACT ON PTZ- INDUCED SEIZURE THRESHOLD IN MICE. JOURNAL OF VETERINARY MICROBIOLOGY[Internet]. 2011;7(21 (SUPPLEMENTARY)):43-47. Available from: https://sid.ir/paper/152126/en

IEEE: Copy

M.H. KHAYAT NOURI, and A. NAMVARAN, “EFFECT OF VALERIAN OFFICINALIS ROOT EXTRACT ON PTZ- INDUCED SEIZURE THRESHOLD IN MICE,” JOURNAL OF VETERINARY MICROBIOLOGY, vol. 7, no. 21 (SUPPLEMENTARY), pp. 43–47, 2011, [Online]. Available: https://sid.ir/paper/152126/en

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