CHARACTERISTIC OF IMMUNE RESPONSE INDUCED BY LIVE ATTENUATED GORGAN GOAT POX STRAIN VACCINE AGAINST LUMP SKIN DISEASE IN CATTLE

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

NORIAN R.; AFZAL AHANGRAN N.; VARSHOVI H.R.; AZADMEHR A.

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: JOURNAL OF VETERINARY MICROBIOLOGY Year:2018 | Volume:14 | Issue:1 (36) Page(s): 15-25

Download Full-Text

Persian Verion

View:

2,944

Download:

Cites:

Information Journal Paper

Title

CHARACTERISTIC OF IMMUNE RESPONSE INDUCED BY LIVE ATTENUATED GORGAN GOAT POX STRAIN VACCINE AGAINST LUMP SKIN DISEASE IN CATTLE

Author(s)

NORIAN R. | AFZAL AHANGRAN N. | VARSHOVI H.R. | AZADMEHR A. | Issue Writer Certificate

Keywords

GOAT POX VACCINEQ2

CELLULAR AND HUMORAL IMMUNITYQ1

REAL-TIME PCRQ2

ELISAQ1

MTTQ2

Abstract

Lumpy skin disease virus (LSD), Goatpox virus and Sheeppox virus are members of genus Capripoxvirus of the Poxviridae, which have close genetic similarity. Therefore, the use of CaPV-vaccine strains derived from sheep and goat would be useful to protect cattle against LSD. The aim of this study was to evaluate the immune responses characteristics of available GOAT POX VACCINE against LSD in cattle. All immunized calves were daily examined for any increase of rectal temperature and appearance of adverse reaction for 5 weeks following vaccination. Humoral immune responses were evaluated by serum neutralization test and cellular immune response were evaluated by MTT, REAL-TIME PCR and ELISA tests. The results showed that the Fever and localized swelling at the injection site were observed in vaccinated calves, in comparison to the control group. In assessing of humoral immune response, a significant increase in the neutralizing antibody titer was observed in the vaccinated group in comparison to control group, although this difference in days 35 was higher than the other days (p<0.05). In assessing the cellular immune response, a significant increase was shown for IFN-g gene expression on day 7 and for IL-4 gene expression on day 21 post-vaccination in comparison to day 0 and control group (P<0.05), While the highest cytokine production in cell culture supernatant for IFN-g and IL-4 was observed at day 21 post-vaccination (P<0.05). Also, the lymphocyte proliferation index in vaccinated calves showed a significant increase on day 7, 21, and 35 in comparison to day 0 and control group (P<0.05). According to the results of this study, the results of this study indicated, that goat pox-vaccine due to induction of high level of antibody titer, higher lymphocyte proliferation and IFN-g and IL-4 production has a good immunogenic response, So It considered suitable vaccine to control of LSD.

Cites

No record.

References

No record.

Cite

APA: Copy

NORIAN, R., AFZAL AHANGRAN, N., VARSHOVI, H.R., & AZADMEHR, A.. (2018). CHARACTERISTIC OF IMMUNE RESPONSE INDUCED BY LIVE ATTENUATED GORGAN GOAT POX STRAIN VACCINE AGAINST LUMP SKIN DISEASE IN CATTLE. JOURNAL OF VETERINARY MICROBIOLOGY, 14(1 (36) ), 15-25. SID. https://sid.ir/paper/152173/en

Vancouver: Copy

NORIAN R., AFZAL AHANGRAN N., VARSHOVI H.R., AZADMEHR A.. CHARACTERISTIC OF IMMUNE RESPONSE INDUCED BY LIVE ATTENUATED GORGAN GOAT POX STRAIN VACCINE AGAINST LUMP SKIN DISEASE IN CATTLE. JOURNAL OF VETERINARY MICROBIOLOGY[Internet]. 2018;14(1 (36) ):15-25. Available from: https://sid.ir/paper/152173/en

IEEE: Copy

R. NORIAN, N. AFZAL AHANGRAN, H.R. VARSHOVI, and A. AZADMEHR, “CHARACTERISTIC OF IMMUNE RESPONSE INDUCED BY LIVE ATTENUATED GORGAN GOAT POX STRAIN VACCINE AGAINST LUMP SKIN DISEASE IN CATTLE,” JOURNAL OF VETERINARY MICROBIOLOGY, vol. 14, no. 1 (36) , pp. 15–25, 2018, [Online]. Available: https://sid.ir/paper/152173/en

Related Journal Papers