EFFECT OF ROSMARINUS OFFICINALIS L. AERIAL PARTS EXTRACT AND FRACTIONS ON MORPHINE WITHDRAWAL SYNDROME IN MICE

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HOSSEINZADEH H.; RAMEZANI MOHAMMAD; SHAHSAVAND SH.

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Journal: Journal of Medicinal Plants Year:2006 | Volume:5 | Issue:20 Page(s): 27-35

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Title

EFFECT OF ROSMARINUS OFFICINALIS L. AERIAL PARTS EXTRACT AND FRACTIONS ON MORPHINE WITHDRAWAL SYNDROME IN MICE

Author(s)

HOSSEINZADEH H. | RAMEZANI MOHAMMAD | SHAHSAVAND SH. | Issue Writer Certificate

Keywords

ROSMARINUS OFFICINALISQ4

WITHDRAWAL SYNDROMEQ4

FRACTIONQ4

MORPHINEQ4

OPIOID SYSTEMQ4

Abstract

Background: Our previous studies have shown that the aqueous and ethanolic extracts of ROSMARINUS OFFICINALIS L. aerial parts reduce MORPHINE WITHDRAWAL SYNDROME in mice.Objective: As R. officinalis L. aerial parts total extracts reduced MORPHINE WITHDRAWAL SYNDROME, we decided to evaluate the effects of rosemary extract FRACTIONs on the WITHDRAWAL SYNDROME.Method: Dependence was induced using subcutaneous injections of MORPHINE daily for three days (50, 50 and 75 mg/kg). On the fourth day, MORPHINE was injected two hours prior to the intraperitoneal injection of naloxone. The number of jumps during the 30 minute period after naloxone injection was considered as measure of the WITHDRAWAL SYNDROME.Results: The results indicate that the aqueous, methanolic-aqueous and chlorformic FRACTIONs (0.96 g/kg and 1.68 g/kg, i.p.) and also clonidine (0.3 mg/kg) and diazepam (5 mg/kg) reduce the number of jumps when they are injecte 1 h prior the last dose of MORPHINE. Two evaluable MPLC chloroformic FRACTIONs also reduce the number of jumping in mice. In the open field activity, test, on the contrary of FRACTION 2, the FRACTION 1 and clonidine reduce locomotor activity.Conclusion: It is concluded that the reduction of withdrawal MORPHINE syndrome by R. officinalis aerial parts FRACTION 1 may be due to the reduction of movement by this FRACTION, but the FRACTION 2 may reduce WITHDRAWAL SYNDROME via an interaction with OPIOID SYSTEM.

Cites

BIOMASS PRODUCTION AND HEAVY METAL CONTENT OF ROSMARINUS OFFICINALIS GROWN ON MSW COMPOST AND CATTLE MANURE

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APA: Copy

HOSSEINZADEH, H., RAMEZANI, MOHAMMAD, & SHAHSAVAND, SH.. (2006). EFFECT OF ROSMARINUS OFFICINALIS L. AERIAL PARTS EXTRACT AND FRACTIONS ON MORPHINE WITHDRAWAL SYNDROME IN MICE. JOURNAL OF MEDICINAL PLANTS, 5(20), 27-35. SID. https://sid.ir/paper/15248/en

Vancouver: Copy

HOSSEINZADEH H., RAMEZANI MOHAMMAD, SHAHSAVAND SH.. EFFECT OF ROSMARINUS OFFICINALIS L. AERIAL PARTS EXTRACT AND FRACTIONS ON MORPHINE WITHDRAWAL SYNDROME IN MICE. JOURNAL OF MEDICINAL PLANTS[Internet]. 2006;5(20):27-35. Available from: https://sid.ir/paper/15248/en

IEEE: Copy

H. HOSSEINZADEH, MOHAMMAD RAMEZANI, and SH. SHAHSAVAND, “EFFECT OF ROSMARINUS OFFICINALIS L. AERIAL PARTS EXTRACT AND FRACTIONS ON MORPHINE WITHDRAWAL SYNDROME IN MICE,” JOURNAL OF MEDICINAL PLANTS, vol. 5, no. 20, pp. 27–35, 2006, [Online]. Available: https://sid.ir/paper/15248/en

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