THE EFFECT OF HYDRO-ALCOHOLIC EXTRACTS OF ANETHUM GRAVEOLENS L. (DILL) ON AMYGDALA KINDLED IN RATS

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AZHDARI ZARMEHRI H.; KAMALIMANESH B.; ABARSHI A.; NAFISI FARD R.; MOHEBI E.; SHAMSIZADEH A.; PEZHHAN A.; MOHAMMADZADEH M.

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Journal: Journal of Medicinal Plants Year:2018 | Volume:17 | Issue:68 Page(s): 41-48

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Title

THE EFFECT OF HYDRO-ALCOHOLIC EXTRACTS OF ANETHUM GRAVEOLENS L. (DILL) ON AMYGDALA KINDLED IN RATS

Author(s)

Keywords

ANETHUM GRAVEOLENS L.Q1

AMYGDALA KINDLINGQ3

EPILEPSYQ2

RATQ1

SEIZUREQ3

Abstract

Background: Although hydro-alcoholic extracts of ANETHUM GRAVEOLENS L. had Anticonvulsants effect on PTZ-induced kindling SEIZURE behavior, but on the AMYGDALA KINDLING in RATs induced SEIZURE has not been investigated.Objective: In this study, we evaluated the chronic effects of hydro-alcoholic extracts of Anethum graveolensL. on SEIZUREs using electrical AMYGDALA KINDLING model.Methods: RATs were divided into six groups. They were kindled by stimulating the amygdala by consecutive daily. Then, treated by hydro-alcoholic extracts of ANETHUM GRAVEOLENS L. (i.p.100, 200 and 400 mg/kg) and After discharge Duration (ADD), Stage 4 latency (S4L) and Stage 5 duration (S5D) were recorded.Results: Hydro-alcoholic extracts of ANETHUM GRAVEOLENS L. (200 and 400 mg/kg) significantly increased stage 4 latency compare to the control group (P<0.05). Hydro-alcoholic extracts of Anethum graveolensL. (400 mg/kg) injection stage 5 duration caused by amygdala electrical kindling. Hydro-alcoholic extracts of ANETHUM GRAVEOLENS L. (100, 200 and 400 mg/kg) injection significantly reduced ADD induced by AMYGDALA KINDLING.Conclusion: The data showed that injection of hydro-alcoholic extracts of ANETHUM GRAVEOLENS L. has anti-epileptic effect and increases the time required for AMYGDALA KINDLING and may have anticonvulsant effects.

Cites

Newest Targets for Anticonvulsant Agents: An Overview

References

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APA: Copy

AZHDARI ZARMEHRI, H., KAMALIMANESH, B., ABARSHI, A., NAFISI FARD, R., MOHEBI, E., SHAMSIZADEH, A., PEZHHAN, A., & MOHAMMADZADEH, M.. (2018). THE EFFECT OF HYDRO-ALCOHOLIC EXTRACTS OF ANETHUM GRAVEOLENS L. (DILL) ON AMYGDALA KINDLED IN RATS. JOURNAL OF MEDICINAL PLANTS, 17(68 ), 41-48. SID. https://sid.ir/paper/15288/en

Vancouver: Copy

AZHDARI ZARMEHRI H., KAMALIMANESH B., ABARSHI A., NAFISI FARD R., MOHEBI E., SHAMSIZADEH A., PEZHHAN A., MOHAMMADZADEH M.. THE EFFECT OF HYDRO-ALCOHOLIC EXTRACTS OF ANETHUM GRAVEOLENS L. (DILL) ON AMYGDALA KINDLED IN RATS. JOURNAL OF MEDICINAL PLANTS[Internet]. 2018;17(68 ):41-48. Available from: https://sid.ir/paper/15288/en

IEEE: Copy

H. AZHDARI ZARMEHRI, B. KAMALIMANESH, A. ABARSHI, R. NAFISI FARD, E. MOHEBI, A. SHAMSIZADEH, A. PEZHHAN, and M. MOHAMMADZADEH, “THE EFFECT OF HYDRO-ALCOHOLIC EXTRACTS OF ANETHUM GRAVEOLENS L. (DILL) ON AMYGDALA KINDLED IN RATS,” JOURNAL OF MEDICINAL PLANTS, vol. 17, no. 68 , pp. 41–48, 2018, [Online]. Available: https://sid.ir/paper/15288/en

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