Immunohistochemical Analysis of Oral Spindle Cell Hemangioma

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Mani Amit; Bajpai Manas; Sabnis Saurabh L.

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Journal Paper

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Journal: Journal of Dentistry Year:2025 | Volume:26 | Issue:2 Page(s): 194-198

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Title

Immunohistochemical Analysis of Oral Spindle Cell Hemangioma

Author(s)

Mani Amit | Bajpai Manas | Sabnis Saurabh L. | Issue Writer Certificate

Keywords

Hemangioma

Immunohistochemistry

Hemangioendothelioma

palate

Abstract

Spindle cell Hemangioma (SCH), formerly called “spindle cell Hemangioendothelioma”, is a rare benign histological variant of Hemangioma characterized by the presence of two contrast zones, the first zone exhibits large dilated cavernous space with slit-like vascular spaces may show clear endothelial vacuoles resembling fat cells. SCH is often considered as pseudosarcomatous entity; it imposes a diagnostic challenge for oral pathologists due to its resemblance with Kaposi sarcoma. A total of 13 cases of SCH have been reported in the head and neck region to date and only 6 cases have been reported inside the oral cavity. We present a rare case of SCH located on the hard palate, which imitated Kaposi's sarcoma on histopathological examination. The expressions of various markers including EGR, CD 31, and HHV 8 yielded the final diagnosis of SCH. The markers EGR and HHV 8 have never been used in intraoral SCH before to the best of our knowledge; hence, the present report highlights the use of Immunohistochemistry for the diagnosis of SCH.

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