Synthesis, Formulation, and Characterization of Niosome Loaded Gingerol Coated Chitosan: Evaluation of Its Antimicrobial, Anticancer, and Biocompatibility Effects: A Laboratory Study

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Mirzaie Amir

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Journal Paper

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Journal: Journal of Rafsanjan University of Medical Sciences Year:2024 | Volume:23 | Issue:10 Page(s): 887-903

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Title

Synthesis, Formulation, and Characterization of Niosome Loaded Gingerol Coated Chitosan: Evaluation of Its Antimicrobial, Anticancer, and Biocompatibility Effects: A Laboratory Study

Author(s)

Mirzaie Amir | Issue Writer Certificate

Keywords

Niosome

Chitosan

Gingerol

Antimicrobial effects

Anticancer effects

Abstract

Background and Objectives: Gingerol is one of the most important phenolic compounds found in the ginger plant, and targeting the transfer of effective plant compounds to cells is one of the important challenges of researchers. The aim of this study was to load Gingerol in Niosome nanocarrier coated with Chitosan and determine its antimicrobial and Anticancer effects. Materials and Methods: In this laboratory study, Niosome nanocarrier containing Gingerol was synthesized and then, synthesized Niosomes were coated with Chitosan and its structural properties were investigated. The antimicrobial and anti-biofilm effects of the synthesized Niosomes were investigated using the microdilution method. Also, Anticancer effects and biocompatibility of synthesized Niosomes were evaluated using colorimetric method. Data were analyzed using one-way ANOVA. Results: Examining the structure of Niosomes containing Gingerol coated with Chitosan showed that it has a spherical structure and an average size of 102. 56±5. 80 nm. Also, the results of Fourier transform infrared spectroscopy (FTIR) confirmed the synthesis of Niosomes. The results showed that the synthesized Niosomes increased the Antimicrobial effects 1 to 4 times, and at concentrations of 100 and 200 µg/ml, cell survival was decreased 24. 66±1. 39% and 16. 65±1. 12%, respectively (p<0. 05). Also, the synthesized Niosomes did not have any significant cytotoxic effects against the human foreskin fibroblasts (HFF) cell line (p>0. 05). Conclusion: The results showed that the synthesized Niosomes can increase the antimicrobial, anti-biofilm, and anti-cancer effects of Gingerol, and therefore this nanocarrier can be used for targeted delivery of effective herbal compounds.

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