INCREASED PODOPHYLLOTOXIN PRODUCTION AND PHENYLALANINE AMMONIA LYASE ACTIVITY IN CELL CULTURE OF LINUM ALBUM BY METHYL JASMONATE

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FAKHARI S.; SHARIFI M.

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Journal: Journal of Plant Production Research Year:2014 | Volume:20 | Issue:4 Page(s): 163-176

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Title

INCREASED PODOPHYLLOTOXIN PRODUCTION AND PHENYLALANINE AMMONIA LYASE ACTIVITY IN CELL CULTURE OF LINUM ALBUM BY METHYL JASMONATE

Author(s)

FAKHARI S. | SHARIFI M. | Issue Writer Certificate

Keywords

CELL CULTUREQ2

LINUM ALBUMQ2

METHYL JASMONATEQ2

PODOPHYLLOTOXINQ2

Abstract

Linum album L. contains pharmaceutical composition PODOPHYLLOTOXIN (PTOX) which is currently being used as a precursor to semi-synthetic anticancer drugs etoposide, teniposide and etopophos. CELL CULTURE is an important source for the production of PTOX. Several strategies, including treatment with elicitors have shown for enhanced production of secondary metabolites in CELL CULTURE system as well as elicitor concentration, the time of application and type of medium culture. These factors affect signal transduction pathways, leading to changes in gen expression and the production of metabolites as defense responses against stress. In a time course study, the effect of 100 mM METHYL JASMONATE on accumulation of PTOX was studied after 1, 6, 12, 24, 48 and 72 h in CELL CULTURE system. According to the results, cell growth was not changed by treatments. PODOPHYLLOTOXIN production was enhanced and received to 0.32 mg/g dry weight after 48 h. To understand the functional of METHYL JASMONATE on biosynthesis of PTOX was determined phenyl alanine ammonia lyase (PAL) activity. This activity promoted 6 h after the addition of METHYL JASMONATE to the cell suspension culture. The enhancement of PTOX correspond the PAL activity increment.

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APA: Copy

FAKHARI, S., & SHARIFI, M.. (2014). INCREASED PODOPHYLLOTOXIN PRODUCTION AND PHENYLALANINE AMMONIA LYASE ACTIVITY IN CELL CULTURE OF LINUM ALBUM BY METHYL JASMONATE. JOURNAL OF PLANT PRODUCTION (JOURNAL OF AGRICULTURAL SCIENCES AND NATURAL RESOURCES), 20(4), 163-176. SID. https://sid.ir/paper/155793/en

Vancouver: Copy

FAKHARI S., SHARIFI M.. INCREASED PODOPHYLLOTOXIN PRODUCTION AND PHENYLALANINE AMMONIA LYASE ACTIVITY IN CELL CULTURE OF LINUM ALBUM BY METHYL JASMONATE. JOURNAL OF PLANT PRODUCTION (JOURNAL OF AGRICULTURAL SCIENCES AND NATURAL RESOURCES)[Internet]. 2014;20(4):163-176. Available from: https://sid.ir/paper/155793/en

IEEE: Copy

S. FAKHARI, and M. SHARIFI, “INCREASED PODOPHYLLOTOXIN PRODUCTION AND PHENYLALANINE AMMONIA LYASE ACTIVITY IN CELL CULTURE OF LINUM ALBUM BY METHYL JASMONATE,” JOURNAL OF PLANT PRODUCTION (JOURNAL OF AGRICULTURAL SCIENCES AND NATURAL RESOURCES), vol. 20, no. 4, pp. 163–176, 2014, [Online]. Available: https://sid.ir/paper/155793/en

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