ANTI-ANXIETY EFFECT OF AQUEOUS AND ETHANOLIC EXTRACTS OF SALVIA LERIIFOLIA BENTH. LEAVES IN MICE USING ELEVATED PLUS MAZE

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HOSSEINZADEH HOSSEIN; DANAEI A.; ZIAEI S.T.

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Journal: Journal of Medicinal Plants Year:2008 | Volume:7 | Issue:27 Page(s): 25-36

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Title

ANTI-ANXIETY EFFECT OF AQUEOUS AND ETHANOLIC EXTRACTS OF SALVIA LERIIFOLIA BENTH. LEAVES IN MICE USING ELEVATED PLUS MAZE

Author(s)

HOSSEINZADEH HOSSEIN | DANAEI A. | ZIAEI S.T. | Issue Writer Certificate

Keywords

SALVIA LERIIFOLIA BENTH. LEAFQ3

ANTI-ANXIETYQ3

ELEVATED PLUS MAZEQ3

LOCOMOTION ACTIVITYQ4

MOTOR BALANCEQ3

Abstract

Background: Salvia leriifolia (Lamiaceae) is indigenous to the east of Iran and some part of Afghanestan. It has many pharmacological effects such as antinociceptive, anti-inflammatory, anti-ischemic, anti-hyperglycemic, hypnotic, muscle relexant, anti-peptic ulcer and anticonvulsant effects.Objective: In this research, the antianxiety effects of aqueous and ethanolic extracts of S. leriifolia Benth. leaves were studied using ELEVATED PLUS MAZE.Method: Nine groups of male mice were used, each of which contained 7-10 animals. Half an hour before ANTI-ANXIETY test, the aqueous or ethanolic extracts (100, 200 and 400 mg/kg), diazepam (1 mg/kg) and saline were injected intraperitoneally to mice. The aqueous and ethanolic extracts were dissolved in saline or tween 80, respectively. In ANTI-ANXIETY test, the number of entries into open and closed arms by animals was recorded. In motor coordination (Rotarod test) experiment, the extracts were injected 30 or 60 min before the test and in locomotor activity (open field test) experiment, the extracts were injected 60 min before test.Results: In anti - anxiety test, among different doses of the aqueous or ethanolic extracts, only ethanolic extract (in dose of 100 and 200 mg/kg) significantly increased opened arms entrance (p<0.01) and all doses of the ethanolic and aqueous extracts declined closed arms entrance, dose dependently (p<0.001). In Rotarod and open field tests all of doses significantly decreased mice LOCOMOTION ACTIVITY and MOTOR BALANCE (p<0.001).Conclusion: The ethanolic extract of S. leriifolia leaves extract showed ANTI-ANXIETY activity and declined LOCOMOTION ACTIVITY and motor coordination in mice.

Cites

STUDY OF THE ANXIOLYTIC EFFECTS OF PLANTGO MAJOR L. AND POSSIBLE ROLE OF GABAERGIC SYSTEM IN THESE EFFECTS IN RATS

References

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APA: Copy

HOSSEINZADEH, HOSSEIN, DANAEI, A., & ZIAEI, S.T.. (2008). ANTI-ANXIETY EFFECT OF AQUEOUS AND ETHANOLIC EXTRACTS OF SALVIA LERIIFOLIA BENTH. LEAVES IN MICE USING ELEVATED PLUS MAZE. JOURNAL OF MEDICINAL PLANTS, 7(27), 25-36. SID. https://sid.ir/paper/15588/en

Vancouver: Copy

HOSSEINZADEH HOSSEIN, DANAEI A., ZIAEI S.T.. ANTI-ANXIETY EFFECT OF AQUEOUS AND ETHANOLIC EXTRACTS OF SALVIA LERIIFOLIA BENTH. LEAVES IN MICE USING ELEVATED PLUS MAZE. JOURNAL OF MEDICINAL PLANTS[Internet]. 2008;7(27):25-36. Available from: https://sid.ir/paper/15588/en

IEEE: Copy

HOSSEIN HOSSEINZADEH, A. DANAEI, and S.T. ZIAEI, “ANTI-ANXIETY EFFECT OF AQUEOUS AND ETHANOLIC EXTRACTS OF SALVIA LERIIFOLIA BENTH. LEAVES IN MICE USING ELEVATED PLUS MAZE,” JOURNAL OF MEDICINAL PLANTS, vol. 7, no. 27, pp. 25–36, 2008, [Online]. Available: https://sid.ir/paper/15588/en

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