ANALGESIC EFFECT OF FENUGREEK LEAF EXTRACT IN MALE STREPTOZOTOCIN DIABETIC RATS.

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ROUGHANI M.; VAEZ MAHDAVI M.R.; KHALILI M.; MIRI S.R.A.; ANSARI F.; YADEGARI S.

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Journal: Journal of Medicinal Plants Year:2003 | Volume:2 | Issue:8 Page(s): 41-46

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Information Journal Paper

Title

ANALGESIC EFFECT OF FENUGREEK LEAF EXTRACT IN MALE STREPTOZOTOCIN DIABETIC RATS.

Author(s)

Keywords

DIABETES MELLITUSQ4

TRIGONELLA FOENUM - GRAECUMQ4

PAINQ4

ANTINOCICEPTIONQ3

FORMALIN TESTQ3

RAT.Q3

Abstract

Diabetic RAT. display exaggerated hyperalgesic behavior in response to noxious stimuli that may resemble and model aspects of PAINful diabetic neuropathy in humans. This study was designed to investigate the effect of TRIGONELLA FOENUM - GRAECUM (TFG) on formalin - induced nociceptive responses (standard FORMALIN TEST) in streptozotocin (STZ) - induced diabetic RAT.. For this purpose, STZ - diabetic RAT. received intraperitoneal injection of aqueous leaf extract of TFG (200 mg/kg every other day for a period of one month). Tt was found out that TFG treatment did cause a significant reduction in blood glucose in diabetic RAT. and TFG - treated diabetic RAT. exhibited a lower nociceptive score as compared to untreated - diabetic ones. Meanwhile TFG treatment reduced the nociceptive score in both phases of the FORMALIN TEST. In contrast. Sodium salicylate as positive control only reduced this score in the second phase of the test. The results suggest therapeutic potential of aqueous extract of fenugreek for treating PAINful diabetic neuropathy.

Cites

ASSESSMENT OF THE EFFECT OF HYDRO-ALCOHOLIC EXTRACT OF TRIGONELLA FOENUM ON ANXIETY AND SLEEP IN MICE

References

POTENTIAL MECHANISMS OF NEUROPATHIC PAIN IN DIABETES

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APA: Copy

ROUGHANI, M., VAEZ MAHDAVI, M.R., KHALILI, M., MIRI, S.R.A., ANSARI, F., & YADEGARI, S.. (2003). ANALGESIC EFFECT OF FENUGREEK LEAF EXTRACT IN MALE STREPTOZOTOCIN DIABETIC RATS.. JOURNAL OF MEDICINAL PLANTS, 2(8), 41-46. SID. https://sid.ir/paper/15678/en

Vancouver: Copy

ROUGHANI M., VAEZ MAHDAVI M.R., KHALILI M., MIRI S.R.A., ANSARI F., YADEGARI S.. ANALGESIC EFFECT OF FENUGREEK LEAF EXTRACT IN MALE STREPTOZOTOCIN DIABETIC RATS.. JOURNAL OF MEDICINAL PLANTS[Internet]. 2003;2(8):41-46. Available from: https://sid.ir/paper/15678/en

IEEE: Copy

M. ROUGHANI, M.R. VAEZ MAHDAVI, M. KHALILI, S.R.A. MIRI, F. ANSARI, and S. YADEGARI, “ANALGESIC EFFECT OF FENUGREEK LEAF EXTRACT IN MALE STREPTOZOTOCIN DIABETIC RATS.,” JOURNAL OF MEDICINAL PLANTS, vol. 2, no. 8, pp. 41–46, 2003, [Online]. Available: https://sid.ir/paper/15678/en

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