ANTILEISHMANIAL ACTIVITY OF NANOLIPOSOMES CONTAINING CURCUMIN IN VITRO AND IN VIVO

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AKBARI MORTEZA; ASKARI ZADEH ANIS; SADRI KEYVAN; IRANSHAHI MEHRDAD; JAAFARI MAHMOUD REZA; KHAMESIPOUR ALI; BADIEE ALI

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Journal: Dermatology and Cosmetics Year:2018 | Volume:8 | Issue:4 Page(s): 204-217

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Title

ANTILEISHMANIAL ACTIVITY OF NANOLIPOSOMES CONTAINING CURCUMIN IN VITRO AND IN VIVO

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Keywords

CURCUMINQ1

LEISHMANIASISQ1

L. MAJORQ1

LIPOSOMEQ2

Abstract

Background and Aim: CURCUMIN possesses diverse pharmacologic effects including anti-inflammatory, antioxidant, antiproliferative and antiangiogenic activities. The aim of this study was to develop liposomal formulation of CURCUMIN and evaluate the leishmanial effects of its topical use against L. MAJOR in vitro and in vivo.Methods: Nanoliposomes containing 1, 2 or 3% curumin were prepared by fusion method and characterized for their size, morphology and stability. The in vitro efficacy of liposomal form of CURCUMIN against promastigotes and amastigotes form of L. MAJOR was also evaluated. Moreover, the leishmanial effect of formulations was evaluated in infected BALB/c mice. The lesions were treated topically by different formulations twice a day, for 4 weeks. During this time and 4 weeks after treatment, lesions size was measured every week. The level of splenic parasite burdens was investigated in week 4 after parasite inoculation.Results: CURCUMIN showed no leishmanicidal effect against live promasigotes and amastigotes in culture media. There was no significant difference between treated and control animals regarding lesion size and splenic parasite burden.Conclusion: The results of this study showed that nanoliposomes containing CURCUMIN in topical form has no significant leishmanicidal effect in vitro and in vivo against L. MAJOR.

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APA: Copy

AKBARI, MORTEZA, ASKARI ZADEH, ANIS, SADRI, KEYVAN, IRANSHAHI, MEHRDAD, JAAFARI, MAHMOUD REZA, KHAMESIPOUR, ALI, & BADIEE, ALI. (2018). ANTILEISHMANIAL ACTIVITY OF NANOLIPOSOMES CONTAINING CURCUMIN IN VITRO AND IN VIVO. DERMATOLOGY AND COSMETIC, 8(4 ), 204-217. SID. https://sid.ir/paper/157565/en

Vancouver: Copy

AKBARI MORTEZA, ASKARI ZADEH ANIS, SADRI KEYVAN, IRANSHAHI MEHRDAD, JAAFARI MAHMOUD REZA, KHAMESIPOUR ALI, BADIEE ALI. ANTILEISHMANIAL ACTIVITY OF NANOLIPOSOMES CONTAINING CURCUMIN IN VITRO AND IN VIVO. DERMATOLOGY AND COSMETIC[Internet]. 2018;8(4 ):204-217. Available from: https://sid.ir/paper/157565/en

IEEE: Copy

MORTEZA AKBARI, ANIS ASKARI ZADEH, KEYVAN SADRI, MEHRDAD IRANSHAHI, MAHMOUD REZA JAAFARI, ALI KHAMESIPOUR, and ALI BADIEE, “ANTILEISHMANIAL ACTIVITY OF NANOLIPOSOMES CONTAINING CURCUMIN IN VITRO AND IN VIVO,” DERMATOLOGY AND COSMETIC, vol. 8, no. 4 , pp. 204–217, 2018, [Online]. Available: https://sid.ir/paper/157565/en

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