EFFICACY OF 0.05% ISOTRETINOIN GEL IN COMPARISON WITH CLINDAMYCIN 1% SOLUTION IN THE TREATMENT OF PAPULOPUSTULAR ACNE: A RANDOMIZED CLINICAL TRIAL

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HERIZCHI QADIM HAMIDEH; BABAEI NEJAD SHAHLA; RAHNAMA BADROLSADAT; GOJAZADEH MORTEZA; SHEIKH NAVASI MASOOD

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Journal: Dermatology and Cosmetics Year:2013 | Volume:3 | Issue:4 Page(s): 179-186

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Title

EFFICACY OF 0.05% ISOTRETINOIN GEL IN COMPARISON WITH CLINDAMYCIN 1% SOLUTION IN THE TREATMENT OF PAPULOPUSTULAR ACNE: A RANDOMIZED CLINICAL TRIAL

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Keywords

ACNEQ2

TOPICAL ISOTERTINOINQ2

CLINDAMYCINQ3

Abstract

Background and Aim: ACNE vulgaris is a common disorder of adolescence which may lead to significant cosmetic and psychological problems. Different topical and systemic therapeutic modalities have been used to treat ACNE vulgaris. This study was designed to compare the efficacy of topical 0.05% isotretinoin gel with 1% CLINDAMYCIN solution in the treatment of ACNE vulgaris.Methods: In this randomized clinical trial, 60 patients with mild to moderate papulopustular ACNE vulgaris were randomly allocated into two groups of equal sizes. One group was treated with 0.05% isotretinoin gel every night. The other group was treated with 1% CLINDAMYCIN solution twice daily. Both groups were followed every month for 3 months.Results: The mean of total lesion count decreased significantly after treatment in comparison with its mean before the treatment in both groups (P<0.001). The mean of ACNE severity index significantly reduced after treatment in both groups (P<0.001). Satisfaction of patients in CLINDAMYCIN group was higher (P<0.001).Conclusion: Decrease in total lesion count and ACNE severity index in both treatment groups were statistically significant however, considering the minimal complications and satisfaction of patients in CLINDAMYCIN group, 1% solution of CLINDAMYCIN may be recommended in the treatment of papulopustular of ACNE vulgaris.

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APA: Copy

HERIZCHI QADIM, HAMIDEH, BABAEI NEJAD, SHAHLA, RAHNAMA, BADROLSADAT, GOJAZADEH, MORTEZA, & SHEIKH NAVASI, MASOOD. (2013). EFFICACY OF 0.05% ISOTRETINOIN GEL IN COMPARISON WITH CLINDAMYCIN 1% SOLUTION IN THE TREATMENT OF PAPULOPUSTULAR ACNE: A RANDOMIZED CLINICAL TRIAL. DERMATOLOGY AND COSMETIC, 3(4), 179-186. SID. https://sid.ir/paper/157613/en

Vancouver: Copy

HERIZCHI QADIM HAMIDEH, BABAEI NEJAD SHAHLA, RAHNAMA BADROLSADAT, GOJAZADEH MORTEZA, SHEIKH NAVASI MASOOD. EFFICACY OF 0.05% ISOTRETINOIN GEL IN COMPARISON WITH CLINDAMYCIN 1% SOLUTION IN THE TREATMENT OF PAPULOPUSTULAR ACNE: A RANDOMIZED CLINICAL TRIAL. DERMATOLOGY AND COSMETIC[Internet]. 2013;3(4):179-186. Available from: https://sid.ir/paper/157613/en

IEEE: Copy

HAMIDEH HERIZCHI QADIM, SHAHLA BABAEI NEJAD, BADROLSADAT RAHNAMA, MORTEZA GOJAZADEH, and MASOOD SHEIKH NAVASI, “EFFICACY OF 0.05% ISOTRETINOIN GEL IN COMPARISON WITH CLINDAMYCIN 1% SOLUTION IN THE TREATMENT OF PAPULOPUSTULAR ACNE: A RANDOMIZED CLINICAL TRIAL,” DERMATOLOGY AND COSMETIC, vol. 3, no. 4, pp. 179–186, 2013, [Online]. Available: https://sid.ir/paper/157613/en

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