NEUROPROTECTIVE EFFECT OF VOLUNTARY EXERCISE ON DOPAMINE AND TYROSINE HYDROXYLASE IN THE STRIATUM OF PARKINSONIAN RATS

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AGHASI MOHAMMAD; FALLAH MOHAMMADI ZIYA; HAJIZADEH MOGHADAM AKBAR

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Journal: Journal of Sport Biosciences Year:2013 | Volume:5 | Issue:3 Page(s): 41-52

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Title

NEUROPROTECTIVE EFFECT OF VOLUNTARY EXERCISE ON DOPAMINE AND TYROSINE HYDROXYLASE IN THE STRIATUM OF PARKINSONIAN RATS

Author(s)

AGHASI MOHAMMAD | FALLAH MOHAMMADI ZIYA | HAJIZADEH MOGHADAM AKBAR | Issue Writer Certificate

Keywords

VOLUNTARY EXERCISEQ2

6-HYDROXYDOPAMINEQ2

TYROSINE HYDROXYLASEQ2

DOPAMINEQ2

PARKINSONQ2

RATQ2

Abstract

Introduiction: This study aimed to investigate the protective effects of 12-week VOLUNTARY EXERCISE using a running wheel on the striatum DOPAMINErgic neurons against 6-HYDROXYDOPAMINE lesions in RATs. Materials and method: Twenty five RATs were divided into three groups including healthy, PARKINSON and training-parkinson. The training groups were housed in individual cages geared with running wheels. To induce PARKINSON, 250 microlitre of 6-HYDROXYDOPAMINE (6-OHDA) dissolved in saline was administered intracerebrovenricular (ICV) by a stereotaxic apparatus. TYROSINE HYDROXYLASE and DOPAMINE levels in the striatum were measured by ELISA. The obtained data was analyzed using one-way analysis of variance (ANOVA) and least significant difference (LSD) post-hoc test. Results: The mean running distance of subjects was 5384 meter per day. In this study, DOPAMINE levels between the exercise and PARKINSON control groups had significant differences. In other words, a decrease in the DOPAMINE level was prevented in the training group (P=0.001). DOPAMINE levels in the exercise group remained almost the same level as the healthy group (P=0.129). However, the TYROSINE HYDROXYLASE level did not change in the training and control groups. Conclusion: Pre-treatment with the VOLUNTARY EXERCISE causes an increase in the strength and life-span of DOPAMINErgic neurons striatum against oxidative damage caused by 6-OHDA toxicity, and has a protective role against PARKINSON’s disease.

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APA: Copy

AGHASI, MOHAMMAD, FALLAH MOHAMMADI, ZIYA, & HAJIZADEH MOGHADAM, AKBAR. (2013). NEUROPROTECTIVE EFFECT OF VOLUNTARY EXERCISE ON DOPAMINE AND TYROSINE HYDROXYLASE IN THE STRIATUM OF PARKINSONIAN RATS. SPORT BIOSCIENCES (HARAKAT), 5(3), 41-52. SID. https://sid.ir/paper/159590/en

Vancouver: Copy

AGHASI MOHAMMAD, FALLAH MOHAMMADI ZIYA, HAJIZADEH MOGHADAM AKBAR. NEUROPROTECTIVE EFFECT OF VOLUNTARY EXERCISE ON DOPAMINE AND TYROSINE HYDROXYLASE IN THE STRIATUM OF PARKINSONIAN RATS. SPORT BIOSCIENCES (HARAKAT)[Internet]. 2013;5(3):41-52. Available from: https://sid.ir/paper/159590/en

IEEE: Copy

MOHAMMAD AGHASI, ZIYA FALLAH MOHAMMADI, and AKBAR HAJIZADEH MOGHADAM, “NEUROPROTECTIVE EFFECT OF VOLUNTARY EXERCISE ON DOPAMINE AND TYROSINE HYDROXYLASE IN THE STRIATUM OF PARKINSONIAN RATS,” SPORT BIOSCIENCES (HARAKAT), vol. 5, no. 3, pp. 41–52, 2013, [Online]. Available: https://sid.ir/paper/159590/en

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