INVESTIGATION OF ANTIBODIES AGAINST BORRELIA ANTIGENS IN SERUM AND CSF OF MS PATIENTS

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

RASTI A.; MOAZENI S.M.; SANATI M.H.

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: Cell Journal (Yakhteh) Year:2003 | Volume:5 | Issue:17 Page(s): 35-41

Download Full-Text

Persian Verion

View:

1,492

Download:

Cites:

Information Journal Paper

Title

INVESTIGATION OF ANTIBODIES AGAINST BORRELIA ANTIGENS IN SERUM AND CSF OF MS PATIENTS

Author(s)

RASTI A. | MOAZENI S.M. | SANATI M.H. | Issue Writer Certificate

Keywords

MULTIPLE SCLEROSIS (MS)Q3

BORRELIAQ3

HUMORAL IMMUNE RESPONSEQ3

Abstract

Introduction: To investigate the role of BORRELIA infections in pathogenesis of multiple sclerosis (MS) the presence of antibody against BORRELIA persica (the most common species of BORRELIA in Iran) in the serum and CSF of MS patients was studied. Material and Methods: The presence of antibodies against BORRELIA persica antigens was studied in the serum and CSF of 50 MS patients and 30 age and sex matched normal controls by immunoblotting. The two most important surface lipoproteins of BORRELIA burgdorferi (OspA & OspD), which were produced by recombinant technology, were also included in the study. Results: The obtained results showed that 33 of 50 patients who were tested and some of normal controls, had antibodies in their serum against BORRELIA protein bands. Fisher’s exact test indicated a significant difference between MS patients and normal controls regarding 43 KDa protein band, which became positive in 7 MS patient but none of our controls. We could not detect positive reaction with BORRELIA surface lipoproteins (OspA & OspD) in serum and CSF of any of our patients or normal controls. Conclusion: Considering our results and a lot of similarities between pathogenesis and clinical manifestation of MS and spirochetal lyme disease there are some evidences for spirochetal basis of MS but its confirmation needs further investigations.

Cites

No record.

References

Cite

APA: Copy

RASTI, A., MOAZENI, S.M., & SANATI, M.H.. (2003). INVESTIGATION OF ANTIBODIES AGAINST BORRELIA ANTIGENS IN SERUM AND CSF OF MS PATIENTS . CELL JOURNAL (YAKHTEH), 5(17), 35-41. SID. https://sid.ir/paper/16214/en

Vancouver: Copy

RASTI A., MOAZENI S.M., SANATI M.H.. INVESTIGATION OF ANTIBODIES AGAINST BORRELIA ANTIGENS IN SERUM AND CSF OF MS PATIENTS . CELL JOURNAL (YAKHTEH)[Internet]. 2003;5(17):35-41. Available from: https://sid.ir/paper/16214/en

IEEE: Copy

A. RASTI, S.M. MOAZENI, and M.H. SANATI, “INVESTIGATION OF ANTIBODIES AGAINST BORRELIA ANTIGENS IN SERUM AND CSF OF MS PATIENTS ,” CELL JOURNAL (YAKHTEH), vol. 5, no. 17, pp. 35–41, 2003, [Online]. Available: https://sid.ir/paper/16214/en

Related Journal Papers