THE ROLE OF ADENOSINE A1 REECEPTORS ACTIVITY OF THE HIPPOCAMPAL CA1 NEURONS ON ENTORHINAL CORTEX ELECTERICAL KINDLED SEIZURES IN RAT

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HEYDARIANPOUR A.; MIRANJAFI-ZADEH J.; FATH ELAHI Y.

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Journal: Cell Journal (Yakhteh) Year:2003 | Volume:5 | Issue:18 Page(s): 113-119

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Title

THE ROLE OF ADENOSINE A1 REECEPTORS ACTIVITY OF THE HIPPOCAMPAL CA1 NEURONS ON ENTORHINAL CORTEX ELECTERICAL KINDLED SEIZURES IN RAT

Author(s)

HEYDARIANPOUR A. | MIRANJAFI-ZADEH J. | FATH ELAHI Y. | Issue Writer Certificate

Keywords

SEIZUREQ3

ENTORHINAL CORTEXQ3

HIPPOCAMPUSQ3

ADENOSINEQ3

KINDLINGQ3

Abstract

Introduction: In this study, the role of ADENOSINE A1 receptors of hippocampal CA1 region neurons onentorhinal cortex kindled SEIZUREs was investigated. Material and Methods: A tripolar(stimulating and recording) electrode was implanted in entorhinalcortex and two guide cannulae were implanted in the CA1 region of the left and right hippocampi of allanimals. A week after surgery, animals were stimulated daily to be kindled. In full kindled animals, N6-cyclohexyladenosine (CHA; 1, 10 and 50µM a selective A1 receptor agonist ) and 1,3- dimethyl -8-cyclohexylxanthine (CPT; 5 and 10µM a selective A1 receptor antagonist) were microinfused (1µl/2min) intothe CA1 region of HIPPOCAMPUS and animals were stimulated at 5, 15 and 120 min after drug injection. Allanimals received artificial cerebrospinal fluid, 24 h before each drug injection and the results were used ascontrol. Results: Obtained data showed that 5 and 15 min after injection, CHA at concentrations of 10 and 50 µM,reduced ENTORHINAL CORTEX afterdischarge and stage 5 SEIZURE durations and increased stage 4 latency. It alsodecreased SEIZURE duration only at concentration of 50µM. CHA (1 µM) did not alter SEIZURE parameters. CPTat concentration of 5µM could not produce any changes in SEIZURE parameters, but at concentration of 10 µM increased after discharge and stage 5 durations and decreased stage 4 latency. Intrahippocampal (CA1 region)pretreatment with CPT (5 µM) before CHA (10 and 50 µM) reduced the effects of CHA on SEIZUREparameters . Conclusion: It may be suggested that hippocampal CA1 region plays an important role in SEIZUREpropagation from ENTORHINAL CORTEX to other brain region/s and activation of ADENOSINE A1 receptors in thisregion have anticonvulsant effects on ENTORHINAL CORTEX kindled SEIZUREs .

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APA: Copy

HEYDARIANPOUR, A., MIRANJAFI-ZADEH, J., & FATH ELAHI, Y.. (2003). THE ROLE OF ADENOSINE A1 REECEPTORS ACTIVITY OF THE HIPPOCAMPAL CA1 NEURONS ON ENTORHINAL CORTEX ELECTERICAL KINDLED SEIZURES IN RAT . CELL JOURNAL (YAKHTEH), 5(18), 113-119. SID. https://sid.ir/paper/16251/en

Vancouver: Copy

HEYDARIANPOUR A., MIRANJAFI-ZADEH J., FATH ELAHI Y.. THE ROLE OF ADENOSINE A1 REECEPTORS ACTIVITY OF THE HIPPOCAMPAL CA1 NEURONS ON ENTORHINAL CORTEX ELECTERICAL KINDLED SEIZURES IN RAT . CELL JOURNAL (YAKHTEH)[Internet]. 2003;5(18):113-119. Available from: https://sid.ir/paper/16251/en

IEEE: Copy

A. HEYDARIANPOUR, J. MIRANJAFI-ZADEH, and Y. FATH ELAHI, “THE ROLE OF ADENOSINE A1 REECEPTORS ACTIVITY OF THE HIPPOCAMPAL CA1 NEURONS ON ENTORHINAL CORTEX ELECTERICAL KINDLED SEIZURES IN RAT ,” CELL JOURNAL (YAKHTEH), vol. 5, no. 18, pp. 113–119, 2003, [Online]. Available: https://sid.ir/paper/16251/en

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