THE EFFECTS OF NITRIC OXIDE ON GENTAMICIN TOXICITY IN ISOLATED PERFUSED RAT KIDNEY

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GHAZNAVI R.; FAGHIHI M.; KADKHODAEI MEHRI; SHAMS S.; MAKKEI N.; JAFARI F.

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Journal: Cell Journal (Yakhteh) Year:2000 | Volume:2 | Issue:7 Page(s): 147-151

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Title

THE EFFECTS OF NITRIC OXIDE ON GENTAMICIN TOXICITY IN ISOLATED PERFUSED RAT KIDNEY

Author(s)

Keywords

NITRIC OXIDEQ3

GENTAMICINQ3

KIDNEYQ4

Abstract

Introduction: There have been many studies in recent years on the role of NITRIC OXIDE (NO) in acute renal failure. In this study, the effects of inhibition or interoduction of No synthase on renal toxicity of GENTAMICIN were investegated. Materials & Methods: Isolated KIDNEYs of male rats were perfused with Tyrode buffer (T) as the control group, T+L-argrinine as group 2, T+L-NAME as group 3, T+gentamicin (G) as group 4, T+L-arginine + urinary enzymes, lactate dehydrogenace and alkaline phosphatase (markers of cell death) were measured.Results: Enzymes activity in group 2, 3 and 5 were not significantly different from the control group, in contrast groups 4, 6 and 5, 4 were significanthy different. Group 6 showed significant increase and group 5 showed a significant decrease in the enzymes activity as compared with group 4. Conclusion: This study suggests that NO can protect KIDNEY from GENTAMICIN toxicity.

Cites

THE ROLE OF NITRIC OXIDE IN PROTECTION OF FUNCTIONAL AND STRUCTURAL CHANGES IN GENTAMICIN NEPHROTOXICITY

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APA: Copy

GHAZNAVI, R., FAGHIHI, M., KADKHODAEI, MEHRI, SHAMS, S., MAKKEI, N., & JAFARI, F.. (2000). THE EFFECTS OF NITRIC OXIDE ON GENTAMICIN TOXICITY IN ISOLATED PERFUSED RAT KIDNEY . CELL JOURNAL (YAKHTEH), 2(7), 147-151. SID. https://sid.ir/paper/16280/en

Vancouver: Copy

GHAZNAVI R., FAGHIHI M., KADKHODAEI MEHRI, SHAMS S., MAKKEI N., JAFARI F.. THE EFFECTS OF NITRIC OXIDE ON GENTAMICIN TOXICITY IN ISOLATED PERFUSED RAT KIDNEY . CELL JOURNAL (YAKHTEH)[Internet]. 2000;2(7):147-151. Available from: https://sid.ir/paper/16280/en

IEEE: Copy

R. GHAZNAVI, M. FAGHIHI, MEHRI KADKHODAEI, S. SHAMS, N. MAKKEI, and F. JAFARI, “THE EFFECTS OF NITRIC OXIDE ON GENTAMICIN TOXICITY IN ISOLATED PERFUSED RAT KIDNEY ,” CELL JOURNAL (YAKHTEH), vol. 2, no. 7, pp. 147–151, 2000, [Online]. Available: https://sid.ir/paper/16280/en

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