Fabrication of Poly(ε-Caprolactone), Hydrophilic and β-Tricalcium Phosphate Layer-by-Layer Nanofibrous Scaffolds for Tissue Engineering

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SOHRABI M.; ABBASI M.; ANSAR M.M.

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Journal: ADVANCED MATERIALS IN ENGINEERING (ESTEGHLAL) Year:2019 | Volume:38 | Issue:1 Page(s): 23-35

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Title

Fabrication of Poly(ε-Caprolactone), Hydrophilic and β-Tricalcium Phosphate Layer-by-Layer Nanofibrous Scaffolds for Tissue Engineering

Author(s)

SOHRABI M. | ABBASI M. | ANSAR M.M. | Issue Writer Certificate

Keywords

ScaffoldQ2

Layer-by-layer electrospinningQ1

Poly(ε-caprolactone)Q1

β-Tricalcium phosphateQ2

Tissue engineeringQ2

Abstract

In this study, using biodegradable polymers, nanofiberouse Scaffolds were fabricated from the Layer-by-layer electrospinning method, including two layer that poly (ε-caprolactone), polyvinylpyrrolidone deposited at first layer and poly (ε-caprolactone), polyvinyl alcohol, β-Tricalcium phosphate at latter. After prepration of Scaffolds, scanning electron microscopy (SEM), swelling, porosity, mechanical properties and biodegradability behavior in buffered saline phosphate solution were studied. The results confirmed the bioactivity and suitable mechanical properties of the layer-by-layer Scaffold. The swelling increase with the addition of hydrophilic polymers and reache 811 ± 214 % in the layer-by-layer Scaffold, which reveald a significant difference compared to pure PCL. The MTT test on the layer-by-layer Scaffold, after 3, 5 and 7 days of rats bone marrow stem cells (rMSC) culture, showed the cell viability of above 80% moreover, cells morphology on the scafold indicated the optimal compatibility of cells on the Scaffold.

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APA: Copy

SOHRABI, M., ABBASI, M., & ANSAR, M.M.. (2019). Fabrication of Poly(ε-Caprolactone), Hydrophilic and β-Tricalcium Phosphate Layer-by-Layer Nanofibrous Scaffolds for Tissue Engineering. ADVANCED MATERIALS IN ENGINEERING (ESTEGHLAL), 38(1 ), 23-35. SID. https://sid.ir/paper/163239/en

Vancouver: Copy

SOHRABI M., ABBASI M., ANSAR M.M.. Fabrication of Poly(ε-Caprolactone), Hydrophilic and β-Tricalcium Phosphate Layer-by-Layer Nanofibrous Scaffolds for Tissue Engineering. ADVANCED MATERIALS IN ENGINEERING (ESTEGHLAL)[Internet]. 2019;38(1 ):23-35. Available from: https://sid.ir/paper/163239/en

IEEE: Copy

M. SOHRABI, M. ABBASI, and M.M. ANSAR, “Fabrication of Poly(ε-Caprolactone), Hydrophilic and β-Tricalcium Phosphate Layer-by-Layer Nanofibrous Scaffolds for Tissue Engineering,” ADVANCED MATERIALS IN ENGINEERING (ESTEGHLAL), vol. 38, no. 1 , pp. 23–35, 2019, [Online]. Available: https://sid.ir/paper/163239/en

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