NEUROTOXIN EEFFECTS OF ROTH 801, A DENTAL SEALER, ON THE SPONTANEOUS BIOELECTRICAL ACTIVITY OF F1 NEURONAL CELLS IN HELIX ASPERSA: USINGC URRENT-CLAMP TECHNIQUE

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KHALIL KHANI H.; ASGARY SAEID; JANAHMADI M.

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Journal: Cell Journal (Yakhteh) Year:2002 | Volume:4 | Issue:15 Page(s): 113-118

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Title

NEUROTOXIN EEFFECTS OF ROTH 801, A DENTAL SEALER, ON THE SPONTANEOUS BIOELECTRICAL ACTIVITY OF F1 NEURONAL CELLS IN HELIX ASPERSA: USINGC URRENT-CLAMP TECHNIQUE

Author(s)

KHALIL KHANI H. | ASGARY SAEID | JANAHMADI M. | Issue Writer Certificate

Keywords

INTRACELLULAR RECORDINGQ3

NEUROTOXICITYQ3

HELIX ASPERSQ3

Abstract

Introduction: Some dental sealers have neurotoxic effects on neuronaltissues. These effects appear to be mediated through the inhibition of ionic channels.INTRACELLULAR RECORDING was performed on neuronal cells tocharacterize the underlying ionic mechanisms of NEUROTOXICITY induced by Roth 801. Materials and Methods: Experiments were carried out on F1 neuronal soma membrane located in the right parietal ganglion of snail, HELIX ASPERSa. The properties of action potential were analyzed using singl eelectrode current clamp method. Roth 801 was applied to the bathing solution in invasive and gradual forms. Results: In the current clamp experiments, several parameters, including, resting membrane potential (RMP), the peak amplitude of action potential, spike width, frequency, the peak amplitude of after hyperpolarization (AHP) were analyzed. In both invasive and gradual forms Roth 801 decreased the peak of amplitude and frequency of action potential and the peak amplitude of AHP. But the duration of spike was prolonged. After invasive application of Roth 801, membrane potential was depolarized. However in gradual method, it was initially hyperpolarized and subsequently shifted towards depolarized potential. Conclusion: These results suggest that Roth 801 affects shape and frequency of action potential through inhibition of ionic currents.

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APA: Copy

KHALIL KHANI, H., ASGARY, SAEID, & JANAHMADI, M.. (2002). NEUROTOXIN EEFFECTS OF ROTH 801, A DENTAL SEALER, ON THE SPONTANEOUS BIOELECTRICAL ACTIVITY OF F1 NEURONAL CELLS IN HELIX ASPERSA: USINGC URRENT-CLAMP TECHNIQUE. CELL JOURNAL (YAKHTEH), 4(15), 113-118. SID. https://sid.ir/paper/16335/en

Vancouver: Copy

KHALIL KHANI H., ASGARY SAEID, JANAHMADI M.. NEUROTOXIN EEFFECTS OF ROTH 801, A DENTAL SEALER, ON THE SPONTANEOUS BIOELECTRICAL ACTIVITY OF F1 NEURONAL CELLS IN HELIX ASPERSA: USINGC URRENT-CLAMP TECHNIQUE. CELL JOURNAL (YAKHTEH)[Internet]. 2002;4(15):113-118. Available from: https://sid.ir/paper/16335/en

IEEE: Copy

H. KHALIL KHANI, SAEID ASGARY, and M. JANAHMADI, “NEUROTOXIN EEFFECTS OF ROTH 801, A DENTAL SEALER, ON THE SPONTANEOUS BIOELECTRICAL ACTIVITY OF F1 NEURONAL CELLS IN HELIX ASPERSA: USINGC URRENT-CLAMP TECHNIQUE,” CELL JOURNAL (YAKHTEH), vol. 4, no. 15, pp. 113–118, 2002, [Online]. Available: https://sid.ir/paper/16335/en

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