مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Persian Verion

Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

video

Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

sound

Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Persian Version

Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

View:

1,058
Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Download:

327
Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Cites:

1

Information Journal Paper

Title

HISTOPATHOLOGICAL EFFECTS OF SINGLE DOSE TREATMENT OF DIAZINON ON TESTES STRUCTURE IN RAT

Pages

  39-42

Abstract

 Objective: DIAZINON (DZN) is an organophosphorate synthetic insecticide widely used in agriculture. DZN has been observed to cause many changes, such as alterations in androgenic hormones. In the present study, the effect of DZN treatment on the structure of the TESTES and SPERMATOGENESIS in young adult Albino RATS was evaluated.Materials and Methods: Adult RATS were randomly divided into three groups including: controls (n=6), DZN-treatment group A (n=6) and DZN-treatment group B (n=6). Commercial DZN was injected intraperitoneally in a single dose (A=25 mg/kg and B=2.5mg/kg), corresponding to LD50. Thirty five days after injection, animals were sacrificed for morphological and histological examinations.Results: There was a significant reduction in seminiferous tubule size in group A in comparison with both controls and group B (p<0.001). The number of spermatocytes, Leydig and germinal cells were significantly decreased (p<0.001). These differences were not significant between the controls and group B; however, the number of spermatocytes in group B was significantly lower than in the controls (p<0.01).Conclusion: This study revealed that the reproductive function of adult RATS and SPERMATOGENESIS are sensitive to DZN treatment. In addition, the effect of DZN on morphological parameters was significantly dose dependent. Further study of the control DZN and the actual mechanism whereby it exerts toxic effects on male infertility is required.

Cites

References

  • No record.
  • Cite

    APA: Copy

    JOURSARAEI, S.GH.A., FIROUZJAEI, A.R., YOUSEFNIA PASHA, Y.R., TAHMASBPOUR MARZOUNI, I., & SARABI, E.. (2010). HISTOPATHOLOGICAL EFFECTS OF SINGLE DOSE TREATMENT OF DIAZINON ON TESTES STRUCTURE IN RAT. CELL JOURNAL (YAKHTEH), 12(1 (45)), 39-42. SID. https://sid.ir/paper/16377/en

    Vancouver: Copy

    JOURSARAEI S.GH.A., FIROUZJAEI A.R., YOUSEFNIA PASHA Y.R., TAHMASBPOUR MARZOUNI I., SARABI E.. HISTOPATHOLOGICAL EFFECTS OF SINGLE DOSE TREATMENT OF DIAZINON ON TESTES STRUCTURE IN RAT. CELL JOURNAL (YAKHTEH)[Internet]. 2010;12(1 (45)):39-42. Available from: https://sid.ir/paper/16377/en

    IEEE: Copy

    S.GH.A. JOURSARAEI, A.R. FIROUZJAEI, Y.R. YOUSEFNIA PASHA, I. TAHMASBPOUR MARZOUNI, and E. SARABI, “HISTOPATHOLOGICAL EFFECTS OF SINGLE DOSE TREATMENT OF DIAZINON ON TESTES STRUCTURE IN RAT,” CELL JOURNAL (YAKHTEH), vol. 12, no. 1 (45), pp. 39–42, 2010, [Online]. Available: https://sid.ir/paper/16377/en

    Related Journal Papers

    Related Seminar Papers

  • No record.
  • Related Plans

  • No record.
  • Recommended Workshops






    Move to top