THE EFFECT OF SODIUM VALPROATE ON THE DEVELOPMENT OF VERTEBRA IN THE MOUSE EMBRYO

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

GOLSHAN IRANPOUR F.; REZAZADEH M.; HOSSEINI A.

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: Cell Journal (Yakhteh) Year:1999 | Volume:1 | Issue:2 Page(s): 21-27

Download Full-Text

Persian Verion

View:

1,197

Download:

Cites:

Information Journal Paper

Title

THE EFFECT OF SODIUM VALPROATE ON THE DEVELOPMENT OF VERTEBRA IN THE MOUSE EMBRYO

Author(s)

GOLSHAN IRANPOUR F. | REZAZADEH M. | HOSSEINI A. | Issue Writer Certificate

Keywords

SODIUM VALPROATEQ4

SPINA BIFIDAQ4

ABNORMALITIES OF VERTEBRAL COLUMNQ4

MOUSE EMBRYO.Q4

Abstract

Introduction: SODIUM VALPROATE is an anti convulsant drug which has been used to treat epileptic patients for last decades. Even a pregnant patient have to use this drug for the treatment of epileptic seizure. The purpose of this investigation is to study the effect of this medicine on the embryo in the mouse. Materials and Methosd: Eight pregnant mice were given 200 mg/kg (i.p.) of SODIUM VALPROATE on the day of gestation at three times intervals at 0,6 and 12 hrs. The control group consisted of seven pregnant mice which were injected sterile distilled water. On day 18 of gestation, all the embryos from both groups were removed, cleared and stained with Alizarine Red and Alcian Blue. Results: The embryos of the experimental group had an increase in the number of cartilage particles of vertebral body, adhesion of vertebral bodies, variability of the numbers of the ossification centers and the adhesion of the lateral ossification centers. Also SPINA BIFIDA occulta was seen. Conclusion: Administration of SODIUM VALPROATE to pregnant mouse can induce a variety of vertebral abnormalities including SPINA BIFIDA occulta.

Cites

No record.

References

Cite

APA: Copy

GOLSHAN IRANPOUR, F., REZAZADEH, M., & HOSSEINI, A.. (1999). THE EFFECT OF SODIUM VALPROATE ON THE DEVELOPMENT OF VERTEBRA IN THE MOUSE EMBRYO . CELL JOURNAL (YAKHTEH), 1(2), 21-27. SID. https://sid.ir/paper/16498/en

Vancouver: Copy

GOLSHAN IRANPOUR F., REZAZADEH M., HOSSEINI A.. THE EFFECT OF SODIUM VALPROATE ON THE DEVELOPMENT OF VERTEBRA IN THE MOUSE EMBRYO . CELL JOURNAL (YAKHTEH)[Internet]. 1999;1(2):21-27. Available from: https://sid.ir/paper/16498/en

IEEE: Copy

F. GOLSHAN IRANPOUR, M. REZAZADEH, and A. HOSSEINI, “THE EFFECT OF SODIUM VALPROATE ON THE DEVELOPMENT OF VERTEBRA IN THE MOUSE EMBRYO ,” CELL JOURNAL (YAKHTEH), vol. 1, no. 2, pp. 21–27, 1999, [Online]. Available: https://sid.ir/paper/16498/en

Related Journal Papers