Simvastatin Neuroprotective Properties against Methylphenidate-Induced Neurodegeneration: Histological and Behavioral Evidence

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: Advanced Biomedical Research Year:2025 | Volume:14 | Issue:September Page(s): 1-7

Download Full-Text

View:

Download:

Cites:

Information Journal Paper

Title

Simvastatin Neuroprotective Properties against Methylphenidate-Induced Neurodegeneration: Histological and Behavioral Evidence

Author(s)

| Issue Writer Certificate

Keywords

Methylphenidate; neurodegeneration; neuroprotective; simvastatin

Abstract

Background: The present study investigated the neuroprotective effect of simvastatin (SIM) against behavioral changes and histological alterations in the hippocampus induced by methylphenidate (MPH). Materials and Methods: Male Wistar rats were divided into the following groups: control, normal saline (0. 2 mL), MPH (10 mg/kg), and MPH (10 mg/kg) plus SIM (10, 20, or 40 mg/kg). Open Field Test (OFT) and Elevated Plus Maze (EPM) evaluated mood and motor activity. Hippocampus DG and CA1 histomorphological changes were also evaluated. Result: MPH caused anxiety, depression, and motor activity disorder in animals in OFT and EPM (P < 0. 001), while SIM altered MPH-induced mood and motor activity disorders in both tests (P < 0. 001). MPH caused quantitative (P < 0. 001) and qualitative changes in hippocampus DG and CA1 cells. SIM (10, 20, and 40 mg/kg) inhibited these neurodegenerative changes of MPH on DG and CA1 cell counts (P < 0. 001) and morphology. Conclusion: SIM conferred neuroprotective properties against MPH-induced behavioral and inhibited MPH-prompted hippocampal cell changes.

Multimedia

No record.

Cites

No record.

References

No record.

Cite

Related Journal Papers

No record.

Related Seminar Papers

No record.

Related Plans