HUMAN GENOME ERA

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KARIMIPOUR MORTEZA

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Journal Paper

Paper Information

Journal: Iranian Journal of Psychiatry and Clinical Psychology Year:2010 | Volume:16 | Issue:3 (62) Page(s): 367-367

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Information Journal Paper

Title

HUMAN GENOME ERA

Author(s)

KARIMIPOUR MORTEZA

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Abstract

The successful completion of Human Genome Project (HGP) on April 2003 revolutionized the efforts to understand the biological pathways involved in mental illness and to develop better methods for prevention, diagnosis, and treatment. Previous researches on genes involved in mental illnesses were concentrated on neurotransmitters and their receptors. However, the focus is now expanding and recent analyses show more than 15,000 genes are active in the mammalian brain. Mapping and sequencing data from HGP have accelerated the discovery of genes responsible of single gene disorders. However, there are not single-gene models for common disorders like mental illnesses, cardiovascular disease and cancer. The risk of developing these disorders is thought to be influenced by different factors including one or more genes, lifestyle and environmental factors. To identify the genetic variation associated with complex disorders like mental illnesses and variation in response to drugs the HapMap project has been launched. Different studies on genomic variations (single nucleotide polymorphism [SNP] and copy number variation [CNV]) in large populations affected with disorders including, schizophrenia, depression, and bipolar disorders are underway. For example, in recent years studies on large populations have linked increased risk of schizophrenia to certain variant of Neuregulin 1 gene. The identification of a gene is the first step in long road toward better diagnostic tests, drug therapies and prevention strategies. Research in this emerging field and examine the genomic information can help the patients affected with mental illnesses to have better specific treatment protocols with fewer side effects.

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APA: Copy

KARIMIPOUR, MORTEZA. (2010). HUMAN GENOME ERA. IRANIAN JOURNAL OF PSYCHIATRY AND CLINICAL PSYCHOLOGY, 16(3 (62)), 367-367. SID. https://sid.ir/paper/17012/en

Vancouver: Copy

KARIMIPOUR MORTEZA. HUMAN GENOME ERA. IRANIAN JOURNAL OF PSYCHIATRY AND CLINICAL PSYCHOLOGY[Internet]. 2010;16(3 (62)):367-367. Available from: https://sid.ir/paper/17012/en

IEEE: Copy

MORTEZA KARIMIPOUR, “HUMAN GENOME ERA,” IRANIAN JOURNAL OF PSYCHIATRY AND CLINICAL PSYCHOLOGY, vol. 16, no. 3 (62), pp. 367–367, 2010, [Online]. Available: https://sid.ir/paper/17012/en

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