COMPARISON OF THE THERAPEUTIC EFFECTS OF SILYMARIN AND NANOSILYMARIN ON HEPATOTOXICITY INDUCED BY TITANIUM DIOXIDE NANOPARTICLES

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HAJIZADEH MOGHADDAM AKBAR; AHMADI AVENDI ELHAM; SAYRAFI REZA; Zare Mahboobeh

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Journal: Avicenna Journal of Clinical Medicine Year:2017 | Volume:23 | Issue:4 (SN 82) Page(s): 345-351

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Title

COMPARISON OF THE THERAPEUTIC EFFECTS OF SILYMARIN AND NANOSILYMARIN ON HEPATOTOXICITY INDUCED BY TITANIUM DIOXIDE NANOPARTICLES

Author(s)

HAJIZADEH MOGHADDAM AKBAR | AHMADI AVENDI ELHAM | SAYRAFI REZA | Zare Mahboobeh | Issue Writer Certificate

Keywords

TITANIUM DIOXIDE NANOPARTICLESQ1

SILYMARINQ1

NANOCRYSTALQ1

LIVER ENZYMESQ1

Abstract

Introduction: Recent studies have indicated that TITANIUM DIOXIDE NANOPARTICLES (TiO2 NPs) are toxic for human. SILYMARIN is a well-known hepatoprotective drug. In this study, the nanoprecipitation technique was used for NANOCRYSTALs to improve the solubility of SILYMARIN. The aim of this study was to analyze the protective role of SILYMARIN and its NANOCRYSTAL on liver damage due to TiO2 NPs in rat.Methods: In this experimental study ,rats were divided to five groups in separate cages: Control ,vehicle ,toxic group (150 mg/kg TiO2 NPs for three weeks orally) as well as SILYMARIN and SILYMARIN NPs groups (100 mg/kg for three weeks orally after TiO2 NPs administration). Then ,the serum level of aspartate transaminase (AST) ,alanine transaminase (ALT) and alkaline phosphatase (ALP) as well as the liver histological changes were investigated.Results: Oral administration of Tio2 NPs resulted in significantly elevated levels of ALT ,AST and ALP of serum and significantly increased the core diameter of hepatocytes (P<0.05). SILYMARIN and its NANOCRYSTAL reduced the elevated liver enzyme levels and also decreased the core diameter of hepatocytes in toxic rats (P<0.001).Conclusion: The results from the present study indicated that SILYMARIN and its NANOCRYSTAL probably due to antioxidant effects cause hepatoprotective against TiO2 NPs-induced liver injury.

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APA: Copy

HAJIZADEH MOGHADDAM, AKBAR, AHMADI AVENDI, ELHAM, SAYRAFI, REZA, & Zare, Mahboobeh. (2017). COMPARISON OF THE THERAPEUTIC EFFECTS OF SILYMARIN AND NANOSILYMARIN ON HEPATOTOXICITY INDUCED BY TITANIUM DIOXIDE NANOPARTICLES. AVICENNA JOURNAL OF CLINICAL MEDICINE (SCIENTIFIC JOURNAL OF HAMADAN UNIVERSITY OF MEDICAL SCIENCES AND HEALTH SERVICES), 23(4 (SN 82)), 345-351. SID. https://sid.ir/paper/17399/en

Vancouver: Copy

HAJIZADEH MOGHADDAM AKBAR, AHMADI AVENDI ELHAM, SAYRAFI REZA, Zare Mahboobeh. COMPARISON OF THE THERAPEUTIC EFFECTS OF SILYMARIN AND NANOSILYMARIN ON HEPATOTOXICITY INDUCED BY TITANIUM DIOXIDE NANOPARTICLES. AVICENNA JOURNAL OF CLINICAL MEDICINE (SCIENTIFIC JOURNAL OF HAMADAN UNIVERSITY OF MEDICAL SCIENCES AND HEALTH SERVICES)[Internet]. 2017;23(4 (SN 82)):345-351. Available from: https://sid.ir/paper/17399/en

IEEE: Copy

AKBAR HAJIZADEH MOGHADDAM, ELHAM AHMADI AVENDI, REZA SAYRAFI, and Mahboobeh Zare, “COMPARISON OF THE THERAPEUTIC EFFECTS OF SILYMARIN AND NANOSILYMARIN ON HEPATOTOXICITY INDUCED BY TITANIUM DIOXIDE NANOPARTICLES,” AVICENNA JOURNAL OF CLINICAL MEDICINE (SCIENTIFIC JOURNAL OF HAMADAN UNIVERSITY OF MEDICAL SCIENCES AND HEALTH SERVICES), vol. 23, no. 4 (SN 82), pp. 345–351, 2017, [Online]. Available: https://sid.ir/paper/17399/en

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