RETINOIC ACID INDUCED LIMB MALFORMATIONS IN MOUSE EMBRYO AND ITS EFFECT ON MATERNAL BLOOD

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AMINI A.; NAJAFIMEHR M.

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Journal: Avicenna Journal of Clinical Medicine Year:2000 | Volume:7 | Issue:3 (SN 17) Page(s): 5-14

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Title

RETINOIC ACID INDUCED LIMB MALFORMATIONS IN MOUSE EMBRYO AND ITS EFFECT ON MATERNAL BLOOD

Author(s)

AMINI A. | NAJAFIMEHR M. | Issue Writer Certificate

Keywords

BLOODQ4

EXTREMITIES-ABNORMALITIESQ4

TRETINOINQ4

Abstract

Retinoic acid (RA) plays key roles in pattern formation along the major body axis and vertebrate limb formation. Exposure to excess retinoic acid in uterus generates congenital malformations in craniofacial, limbs and axial skeleton. The aim of this study was to determine, the retinoic acid induced limb malformations in mouse embryo and its effect on maternal BLOOD. In this study NMRI mice were administered by 100 mg/kg RA on day 9, 10 and 11 of pregnancy. In day 18 of pregnancy embryos were obtained through cesarean section. Maternal BLOOD was examined for hematological studies. Embryos were studied in the case of skeletal elements and histological preparations. The results demonstrate that 9 days embryos carry 37.1% forelimb defects and 31.4% hind limb defects and 100% of 10 and 11 days embryos show limb defects. These defects include shortened or bent limbs, absence of some long bones and a wide range of digital defects. Hematological studies indicated that amounts of hemoglobin and hematocrit as well as number of red and white BLOOD cells were reduced (p<0.05). Therefore, present defects indicated that pregnant women should take care for using retinoic acid, specially during first trimester of pregnancy.

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APA: Copy

AMINI, A., & NAJAFIMEHR, M.. (2000). RETINOIC ACID INDUCED LIMB MALFORMATIONS IN MOUSE EMBRYO AND ITS EFFECT ON MATERNAL BLOOD. AVICENNA JOURNAL OF CLINICAL MEDICINE (SCIENTIFIC JOURNAL OF HAMADAN UNIVERSITY OF MEDICAL SCIENCES AND HEALTH SERVICES), 7(3 (SN 17)), 5-14. SID. https://sid.ir/paper/17425/en

Vancouver: Copy

AMINI A., NAJAFIMEHR M.. RETINOIC ACID INDUCED LIMB MALFORMATIONS IN MOUSE EMBRYO AND ITS EFFECT ON MATERNAL BLOOD. AVICENNA JOURNAL OF CLINICAL MEDICINE (SCIENTIFIC JOURNAL OF HAMADAN UNIVERSITY OF MEDICAL SCIENCES AND HEALTH SERVICES)[Internet]. 2000;7(3 (SN 17)):5-14. Available from: https://sid.ir/paper/17425/en

IEEE: Copy

A. AMINI, and M. NAJAFIMEHR, “RETINOIC ACID INDUCED LIMB MALFORMATIONS IN MOUSE EMBRYO AND ITS EFFECT ON MATERNAL BLOOD,” AVICENNA JOURNAL OF CLINICAL MEDICINE (SCIENTIFIC JOURNAL OF HAMADAN UNIVERSITY OF MEDICAL SCIENCES AND HEALTH SERVICES), vol. 7, no. 3 (SN 17), pp. 5–14, 2000, [Online]. Available: https://sid.ir/paper/17425/en

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