ASSESSMENT OF MYO INOSITOL AND CROCIN EFFECTS ON RAGE AND TGFΒ GENE EXPRESSION IN THE KIDNEY OF STREPTOZOTOCIN INDUCED DIABETIC RATS

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SADAT HEIDARY S.; BAHMANI F.; BATHAEI Z.; MOSHTAGHI KASHANIAN GH.

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Journal: Avicenna Journal of Clinical Medicine Year:2014 | Volume:21 | Issue:2 (SN 72) Page(s): 122-130

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Title

ASSESSMENT OF MYO INOSITOL AND CROCIN EFFECTS ON RAGE AND TGFΒ GENE EXPRESSION IN THE KIDNEY OF STREPTOZOTOCIN INDUCED DIABETIC RATS

Author(s)

SADAT HEIDARY S. | BAHMANI F. | BATHAEI Z. | MOSHTAGHI KASHANIAN GH. | Issue Writer Certificate

Keywords

CROCINQ2

DIABETIC NEPHROPATHYQ2

INOSITOLQ2

GLYCOSYLATION END PRODUCTSQ2

ADVANCEDQ2

Abstract

Introduction & Objective: DIABETIC NEPHROPATHY is one of the micro vascular complications of uncontrolled diabetes. Chronic hyperglycemia results in the formation of glycated proteins and activation of pathways leading to DIABETIC NEPHROPATHY. Increasing RAGE and TGFb production in the kidney tissue is a major pathway involved in diabetic complications. In this survey, the effect of myoinositol and CROCIN on RAGE and TGFb expression in the kidney of diabetic rats was studied.Materials & Methods: In this experimental study after rendering rats with diabetes with streptozotocin, they were treated with oral 1% myoinositol and injection of 100 mg/kg BW CROCIN for 12 weeks. Changes in both RAGE and TGFb expressions in the kidney tissue were assessed by semi-quantitative RT-PCR method. The data was analyzed by SPSS 18 software and one way ANOVA and Tukey statisticaly tests.Results: CROCIN administration caused a significant reduction in the RAGE and TGFb expression in comparison with the untreated diabetic rats. Oral administration of myoinositol could not induce any significant changes in the expression of both genes in the diabetic rats.Conclusion: According to the results of this study, CROCIN has the ability to block pathways leading to DIABETIC NEPHROPATHY through reducing RAGE and TGFb expression in the kidney tissue, maybe through its ability to reduce the serum glucose and AGEs, and antioxidant activity. Considering the positive effects of myoinositol in diabetic complications in previous studies, more studies are needed to find the mechanism of its action.

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APA: Copy

SADAT HEIDARY, S., BAHMANI, F., BATHAEI, Z., & MOSHTAGHI KASHANIAN, GH.. (2014). ASSESSMENT OF MYO INOSITOL AND CROCIN EFFECTS ON RAGE AND TGFΒ GENE EXPRESSION IN THE KIDNEY OF STREPTOZOTOCIN INDUCED DIABETIC RATS. AVICENNA JOURNAL OF CLINICAL MEDICINE (SCIENTIFIC JOURNAL OF HAMADAN UNIVERSITY OF MEDICAL SCIENCES AND HEALTH SERVICES), 21(2 (SN 72)), 122-130. SID. https://sid.ir/paper/17516/en

Vancouver: Copy

SADAT HEIDARY S., BAHMANI F., BATHAEI Z., MOSHTAGHI KASHANIAN GH.. ASSESSMENT OF MYO INOSITOL AND CROCIN EFFECTS ON RAGE AND TGFΒ GENE EXPRESSION IN THE KIDNEY OF STREPTOZOTOCIN INDUCED DIABETIC RATS. AVICENNA JOURNAL OF CLINICAL MEDICINE (SCIENTIFIC JOURNAL OF HAMADAN UNIVERSITY OF MEDICAL SCIENCES AND HEALTH SERVICES)[Internet]. 2014;21(2 (SN 72)):122-130. Available from: https://sid.ir/paper/17516/en

IEEE: Copy

S. SADAT HEIDARY, F. BAHMANI, Z. BATHAEI, and GH. MOSHTAGHI KASHANIAN, “ASSESSMENT OF MYO INOSITOL AND CROCIN EFFECTS ON RAGE AND TGFΒ GENE EXPRESSION IN THE KIDNEY OF STREPTOZOTOCIN INDUCED DIABETIC RATS,” AVICENNA JOURNAL OF CLINICAL MEDICINE (SCIENTIFIC JOURNAL OF HAMADAN UNIVERSITY OF MEDICAL SCIENCES AND HEALTH SERVICES), vol. 21, no. 2 (SN 72), pp. 122–130, 2014, [Online]. Available: https://sid.ir/paper/17516/en

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