Comparison of the Effect of Gabapentin and Evening Primrose Oil on Peripheral Neuropathy Pain in Patients with Type 2 Diabetes

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Nasrabadi Zohre; RAKHSHANI MOHAMMAD HASSAN; Ebadi Hooman; AKBARZADEH ROYA

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Journal: Avicenna Journal of Clinical Medicine Year:2019 | Volume:26 | Issue:1 (SN 91) Page(s): 8-11

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Title

Comparison of the Effect of Gabapentin and Evening Primrose Oil on Peripheral Neuropathy Pain in Patients with Type 2 Diabetes

Author(s)

Nasrabadi Zohre | RAKHSHANI MOHAMMAD HASSAN | Ebadi Hooman | AKBARZADEH ROYA | Issue Writer Certificate

Keywords

Evening PrimroseQ2

GabapentinQ1

NeuropathyQ1

PainQ1

Type 2 Diabetes MellitusQ1

Abstract

Background and Objective: Neuropathic Pain is one of the common, important, and irritating complications in diabetes. Despite the importance of this Pain, there is still no effective treatment for that. The aim of this study was to determine the effect of Evening Primrose oil and Gabapentin on neuropathic Pain in patients with type 2 diabetes. Materials and Methods: This triple-blind clinical trial was performed on 70 patients with diabetic Neuropathy who obtained score 2 from the Michigan Questionnaire and referred to the Department of Endocrinology at Khayyam clinic affiliated to Hakim Hospital in Neyshabour from December 2017 to May 2018. The participants were divided into two groups of 35 people. The intervention group was treated with a capsule of Evening Primrose oil orally (1000 mg) twice daily for three months and Gabapentin (300 mg) daily. On the other hand, the control group was treated with Gabapentin (300 mg) and placebo. The Neuropathy Pain severity was measured before and after the end of three-month intervention using Michigan and McGill Pain Questionnaires. Data analysis was performed in SPSS software (version 21) through Fisher's exact test, ANCOVA, multilevel logistic regression, Mann Whitney U test, Kolmogorov-Smirnov test, and the Chi-square tests. P-value less than 0. 05 was considered statistically significant. Results: According to the results obtained from the McGill questionnaire, the mean scores of Neuropathy before the intervention were obtained at 10. 12± 0. 57 and 9. 85± 0. 65 in the intervention and control groups, respectively. However, the mean scores of Neuropathy after the intervention were estimated at 6. 18± 0. 48 and 8. 31± 0. 60 in the intervention and control groups, respectively, which was statistically significant (P<0. 02). Conclusion: Evening Primrose oil is effective in reducing neuropathic Pain in type 2 diabetic patients. Therefore, this can be a supplementary treatment for reducing Pain associated with diabetic Neuropathy.

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APA: Copy

Nasrabadi, Zohre, RAKHSHANI, MOHAMMAD HASSAN, Ebadi, Hooman, & AKBARZADEH, ROYA. (2019). Comparison of the Effect of Gabapentin and Evening Primrose Oil on Peripheral Neuropathy Pain in Patients with Type 2 Diabetes. AVICENNA JOURNAL OF CLINICAL MEDICINE (SCIENTIFIC JOURNAL OF HAMADAN UNIVERSITY OF MEDICAL SCIENCES AND HEALTH SERVICES), 26(1 (SN 91) ), 8-11. SID. https://sid.ir/paper/17591/en

Vancouver: Copy

Nasrabadi Zohre, RAKHSHANI MOHAMMAD HASSAN, Ebadi Hooman, AKBARZADEH ROYA. Comparison of the Effect of Gabapentin and Evening Primrose Oil on Peripheral Neuropathy Pain in Patients with Type 2 Diabetes. AVICENNA JOURNAL OF CLINICAL MEDICINE (SCIENTIFIC JOURNAL OF HAMADAN UNIVERSITY OF MEDICAL SCIENCES AND HEALTH SERVICES)[Internet]. 2019;26(1 (SN 91) ):8-11. Available from: https://sid.ir/paper/17591/en

IEEE: Copy

Zohre Nasrabadi, MOHAMMAD HASSAN RAKHSHANI, Hooman Ebadi, and ROYA AKBARZADEH, “Comparison of the Effect of Gabapentin and Evening Primrose Oil on Peripheral Neuropathy Pain in Patients with Type 2 Diabetes,” AVICENNA JOURNAL OF CLINICAL MEDICINE (SCIENTIFIC JOURNAL OF HAMADAN UNIVERSITY OF MEDICAL SCIENCES AND HEALTH SERVICES), vol. 26, no. 1 (SN 91) , pp. 8–11, 2019, [Online]. Available: https://sid.ir/paper/17591/en

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