EFFECT OF VARIOUS DOSES OF NICOTINE ON MITOTIC INDEX IN ESOPHAGEAL MUCOSA

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KHAJEH JAHROMI S.; MOHAMMADGHASEMI F.

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Journal: Avicenna Journal of Clinical Medicine Year:2016 | Volume:23 | Issue:2 (SN 80) Page(s): 126-133

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Title

EFFECT OF VARIOUS DOSES OF NICOTINE ON MITOTIC INDEX IN ESOPHAGEAL MUCOSA

Author(s)

KHAJEH JAHROMI S. | MOHAMMADGHASEMI F. | Issue Writer Certificate

Keywords

ESOPHAGEAL MUCOSAQ1

MORPHOMETRYQ1

NICOTINEQ1

PROLIFERATIVE ACTIVITYQ2

Abstract

Introduction & Objective: NICOTINE could directly act as a cancer promoter. The purpose of this study was to evaluate effects of NICOTINE on mitotic index in esophagus epithelium. Materials & Methods: In the present study 30 adult male mice were used. Animals were randomly divided into three groups. Group A or the control group received vehicle, groups B and C received NICOTINE intraperitoneally at doses of 0.2 and 0.4 mg/kg once daily for 14 days, respectively. Evaluations were made using kI-67 immunohistochemistry and Hematoxilin & Eosin for PROLIFERATIVE ACTIVITY and morphometric study on esophagus mucosa, respectively.Results: Administration of NICOTINE in group C, showed a significant increase (P<0.05) in KI- 67 index 34.15±2.50vs. 10.41±1.4 compared with the control subjects. The other parameters such as epithelial height, lamina propria, muscular mucosa and mucosa height in NICOTINEtreated groups were not affected. NICOTINE at dose of 0.2 mg/kg did not change the mitotic index in epithelium when compared with the control group.Conclusion: This study indicates NICOTINE at dose of 0.4 mg/kg increases mitotic activity in basal cells in esophagus epithelium.

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APA: Copy

KHAJEH JAHROMI, S., & MOHAMMADGHASEMI, F.. (2016). EFFECT OF VARIOUS DOSES OF NICOTINE ON MITOTIC INDEX IN ESOPHAGEAL MUCOSA. AVICENNA JOURNAL OF CLINICAL MEDICINE (SCIENTIFIC JOURNAL OF HAMADAN UNIVERSITY OF MEDICAL SCIENCES AND HEALTH SERVICES), 23(2 (SN 80)), 126-133. SID. https://sid.ir/paper/17638/en

Vancouver: Copy

KHAJEH JAHROMI S., MOHAMMADGHASEMI F.. EFFECT OF VARIOUS DOSES OF NICOTINE ON MITOTIC INDEX IN ESOPHAGEAL MUCOSA. AVICENNA JOURNAL OF CLINICAL MEDICINE (SCIENTIFIC JOURNAL OF HAMADAN UNIVERSITY OF MEDICAL SCIENCES AND HEALTH SERVICES)[Internet]. 2016;23(2 (SN 80)):126-133. Available from: https://sid.ir/paper/17638/en

IEEE: Copy

S. KHAJEH JAHROMI, and F. MOHAMMADGHASEMI, “EFFECT OF VARIOUS DOSES OF NICOTINE ON MITOTIC INDEX IN ESOPHAGEAL MUCOSA,” AVICENNA JOURNAL OF CLINICAL MEDICINE (SCIENTIFIC JOURNAL OF HAMADAN UNIVERSITY OF MEDICAL SCIENCES AND HEALTH SERVICES), vol. 23, no. 2 (SN 80), pp. 126–133, 2016, [Online]. Available: https://sid.ir/paper/17638/en

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