COMPARISON OF THERAPEUTIC EFFECT OF ANTI-CRYPTOSPORIDIUM NANO-NITAZOXANIDE (NTZ) WITH FREE FORM OF THIS DRUG IN NEONATAL RAT

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SEDIGHI F.; ABBASALI POURKABIR R.; MAGHSOOD A.H.; FALLAH MOHAMMAD

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Journal: Avicenna Journal of Clinical Medicine Year:2016 | Volume:23 | Issue:2 (SN 80) Page(s): 134-140

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Title

COMPARISON OF THERAPEUTIC EFFECT OF ANTI-CRYPTOSPORIDIUM NANO-NITAZOXANIDE (NTZ) WITH FREE FORM OF THIS DRUG IN NEONATAL RAT

Author(s)

SEDIGHI F. | ABBASALI POURKABIR R. | MAGHSOOD A.H. | FALLAH MOHAMMAD | Issue Writer Certificate

Keywords

CRYPTOSPORIDIUMQ2

NANOMEDICINEQ1

NITAZOXANIDEQ1

SOLID LIPID NANOPARTICLEQ1

Abstract

Introduction & Objective: Cryptosporidiosis caused by CRYPTOSPORIDIUM, which is a protozoan parasite, has a worldwide distribution. The infection is through fecal- oral route, direct or indirect contact, food or water. The treatment of cryptosporidiosis is difficult and the antiparasitic agents are not effective. The purpose of this study was encapsulation of NITAZOXANIDE in solid lipid nano-particles (SLN) and investigation of its anti-CRYPTOSPORIDIUM effect and its comparison with free drug in the neonatal rat.Materials & Methods: NITAZOXANIDE was encapsulated by HPH method with 2 mg/Kg concentration in SLN nanoparticles. The oocysts were collected from calves and purified by sucrose floatation. A total of 72 Wistar neonatal rats were categorized in 6 groups of 12 rats including four infected groups treated by free drug, encapsulated nano drug, colloidal carriers without drug (SLN) and olive oil; an infected control group and a healthy control group that received PBS. 5×105 of oocyts inoculated orally into the sample groups. Finally, intestine of each rat was homogenized in PBS by rotor and the homogenized material was passed through a sieve. Then, floated oocysts in sucrose solution were counted by hemocytometer. Results: Treatment by NITAZOXANIDE significantly decreased the number of parasites in the treatment groups. This decrease at day 6 was more than day 3. Nano NITAZOXANIDE had more effects on parasites than free drug. This difference at day 3 of treatment was not significant (p=0.182) but at day 6 was statistically significant (P<0.001).Conclusion: Using nano- NITAZOXANIDE could be a more effective way in the treatment of ryptosporidium infections.

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APA: Copy

SEDIGHI, F., ABBASALI POURKABIR, R., MAGHSOOD, A.H., & FALLAH, MOHAMMAD. (2016). COMPARISON OF THERAPEUTIC EFFECT OF ANTI-CRYPTOSPORIDIUM NANO-NITAZOXANIDE (NTZ) WITH FREE FORM OF THIS DRUG IN NEONATAL RAT. AVICENNA JOURNAL OF CLINICAL MEDICINE (SCIENTIFIC JOURNAL OF HAMADAN UNIVERSITY OF MEDICAL SCIENCES AND HEALTH SERVICES), 23(2 (SN 80)), 134-140. SID. https://sid.ir/paper/17643/en

Vancouver: Copy

SEDIGHI F., ABBASALI POURKABIR R., MAGHSOOD A.H., FALLAH MOHAMMAD. COMPARISON OF THERAPEUTIC EFFECT OF ANTI-CRYPTOSPORIDIUM NANO-NITAZOXANIDE (NTZ) WITH FREE FORM OF THIS DRUG IN NEONATAL RAT. AVICENNA JOURNAL OF CLINICAL MEDICINE (SCIENTIFIC JOURNAL OF HAMADAN UNIVERSITY OF MEDICAL SCIENCES AND HEALTH SERVICES)[Internet]. 2016;23(2 (SN 80)):134-140. Available from: https://sid.ir/paper/17643/en

IEEE: Copy

F. SEDIGHI, R. ABBASALI POURKABIR, A.H. MAGHSOOD, and MOHAMMAD FALLAH, “COMPARISON OF THERAPEUTIC EFFECT OF ANTI-CRYPTOSPORIDIUM NANO-NITAZOXANIDE (NTZ) WITH FREE FORM OF THIS DRUG IN NEONATAL RAT,” AVICENNA JOURNAL OF CLINICAL MEDICINE (SCIENTIFIC JOURNAL OF HAMADAN UNIVERSITY OF MEDICAL SCIENCES AND HEALTH SERVICES), vol. 23, no. 2 (SN 80), pp. 134–140, 2016, [Online]. Available: https://sid.ir/paper/17643/en

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