A CASE REPORT OF ARTERIAL THROMBOSIS IN WEGENER'S GRANULOMATOSIS PRESENTING WITH ACUTE LOWER LIMB ISCHEMIA

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BASIRI Z.; SHAMS M.; FEREIDUNI M.A.

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Journal: Avicenna Journal of Clinical Medicine Year:2012 | Volume:19 | Issue:1 (SN 63) Page(s): 75-78

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Title

A CASE REPORT OF ARTERIAL THROMBOSIS IN WEGENER'S GRANULOMATOSIS PRESENTING WITH ACUTE LOWER LIMB ISCHEMIA

Author(s)

BASIRI Z. | SHAMS M. | FEREIDUNI M.A. | Issue Writer Certificate

Keywords

ARTERIAL THROMBOSISQ2

ISCHEMIAQ2

WEGENER'S GRANULOMATOSISQ2

Abstract

Introduction: Wegener's Granolomatosis (WG) is a systemic, necrotizing, small-vessel vasculitis. Vascular inflammation and occlusion leading to tissue ISCHEMIA is a hallmark of WG. WG has a clinical predilection for the upper airways, lungs, and kidneys. Thromboembolic events do not usually occur and ARTERIAL THROMBOSIS is extremely rare.Case Report: Here we reported 2 rare cases of ARTERIAL THROMBOSIS that caused lower limb ISCHEMIA. There were not any risk factors such as deficiency of protein C, protein S or anti-thrombin 3, Factor V Leiden mutation, and anti-phospholipids syndrome. Limb perfusion returned as a result of emergency treatment and ISCHEMIA did not occur. High doses of prednisolone and endoxan were administrated for them.Conclusion: The thrombosis seemed to happen due to the inflammation process of the disease itself. Because of possible morbidity of limb gangrene we suggest special notice to limb pain, evaluation by paraclinics such as color doppler sonography or angiography to rule out or rule in thromboembolism, determining whether there are risk factors for thrombosis such as (deficiency of protein C and protein S or anti-thrombin III, Leiden 5 factor mutation and anti-phospholipid antibody syndrome), and treatment or removal of them. If no risk factor is found, high doses of immunosuppressive therapy like steroid and cytotoxic agents like Endoxan will be the choice.

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APA: Copy

BASIRI, Z., SHAMS, M., & FEREIDUNI, M.A.. (2012). A CASE REPORT OF ARTERIAL THROMBOSIS IN WEGENER'S GRANULOMATOSIS PRESENTING WITH ACUTE LOWER LIMB ISCHEMIA. AVICENNA JOURNAL OF CLINICAL MEDICINE (SCIENTIFIC JOURNAL OF HAMADAN UNIVERSITY OF MEDICAL SCIENCES AND HEALTH SERVICES), 19(1 (SN 63)), 75-78. SID. https://sid.ir/paper/17650/en

Vancouver: Copy

BASIRI Z., SHAMS M., FEREIDUNI M.A.. A CASE REPORT OF ARTERIAL THROMBOSIS IN WEGENER'S GRANULOMATOSIS PRESENTING WITH ACUTE LOWER LIMB ISCHEMIA. AVICENNA JOURNAL OF CLINICAL MEDICINE (SCIENTIFIC JOURNAL OF HAMADAN UNIVERSITY OF MEDICAL SCIENCES AND HEALTH SERVICES)[Internet]. 2012;19(1 (SN 63)):75-78. Available from: https://sid.ir/paper/17650/en

IEEE: Copy

Z. BASIRI, M. SHAMS, and M.A. FEREIDUNI, “A CASE REPORT OF ARTERIAL THROMBOSIS IN WEGENER'S GRANULOMATOSIS PRESENTING WITH ACUTE LOWER LIMB ISCHEMIA,” AVICENNA JOURNAL OF CLINICAL MEDICINE (SCIENTIFIC JOURNAL OF HAMADAN UNIVERSITY OF MEDICAL SCIENCES AND HEALTH SERVICES), vol. 19, no. 1 (SN 63), pp. 75–78, 2012, [Online]. Available: https://sid.ir/paper/17650/en

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