EFFECTS OF α1- AND α2-ADRENOCEPTOR AGONIST AND ANTAGONIST IN THE DORSAL HIPPOCAMPUS ON CANNABINOID STATE-DEPENDENT MEMORY

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MOSHFEGH AZAM; BABAEI PARVIN; PIRI MORTEZA; ORYAN SHAHRBANOU; SOLTANI BAHRAM; ZARINDAST M.R.

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Journal: JOURNAL OF ANIMAL BIOLOGY Year:2009 | Volume:1 | Issue:4 Page(s): 59-67

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Title

EFFECTS OF α1- AND α2-ADRENOCEPTOR AGONIST AND ANTAGONIST IN THE DORSAL HIPPOCAMPUS ON CANNABINOID STATE-DEPENDENT MEMORY

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Keywords

CANNABINOIDQ2

Α-ADRENERGIC RECEPTORSQ3

DORSAL HIPPOCAMPUSQ2

INHIBITORY AVOIDANCE RESPONSEQ3

STATE-DEPENDENT LEARNINGQ2

Abstract

CANNABINOIDs are a class of psychoactive compound that produce a wide range of effects in different number of species. The present study evaluated the possible role of α1- and α2-adrenergic receptors of the DORSAL HIPPOCAMPUS on CANNABINOID induced amnesia and CANNABINOID state-dependent memory in adult male Wistar rats. The animals were bilaterally implanted with chronic cannulae in the CA1 regions of the DORSAL HIPPOCAMPUS, trained in a step-down type inhibitory avoidance task, and tested 24h after training to measure step-down latency. Post-training intra-CA1 injection of CANNABINOID receptors agonist, WIN55,212-2 (0.25 and 0.5 µg/rat) induced amnesia. Amnesia induced by post-training WIN55,212-2 (0.5 µg/rat) was restored by pre-test administration of the same dose of WIN55,212-2. Pre-test intra-CA1 injection of phenylephrine could not affect memory but clonidine improved memory impairment induced by WIN55,212-2. Furthermore, microinjection of phenylephrine or clonidine plus an ineffective dose of WIN55,212-2, synergistically restored amnesia induced by WIN55,212-2 . On the other hand, pre-test intra CA1 microinjection of prazosin or yohimbine 2 min before WIN55,212- inhibited pre-test WIN55,212-2 response. These results indicate that Α-ADRENERGIC RECEPTORS of the dorsal hippocampal CA1 regions may play an important role in CANNABINOID-induced amnesia and CANNABINOID state-dependent memory.

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APA: Copy

MOSHFEGH, AZAM, BABAEI, PARVIN, PIRI, MORTEZA, ORYAN, SHAHRBANOU, SOLTANI, BAHRAM, & ZARINDAST, M.R.. (2009). EFFECTS OF α1- AND α2-ADRENOCEPTOR AGONIST AND ANTAGONIST IN THE DORSAL HIPPOCAMPUS ON CANNABINOID STATE-DEPENDENT MEMORY. JOURNAL OF ANIMAL BIOLOGY, 1(4), 59-67. SID. https://sid.ir/paper/176691/en

Vancouver: Copy

MOSHFEGH AZAM, BABAEI PARVIN, PIRI MORTEZA, ORYAN SHAHRBANOU, SOLTANI BAHRAM, ZARINDAST M.R.. EFFECTS OF α1- AND α2-ADRENOCEPTOR AGONIST AND ANTAGONIST IN THE DORSAL HIPPOCAMPUS ON CANNABINOID STATE-DEPENDENT MEMORY. JOURNAL OF ANIMAL BIOLOGY[Internet]. 2009;1(4):59-67. Available from: https://sid.ir/paper/176691/en

IEEE: Copy

AZAM MOSHFEGH, PARVIN BABAEI, MORTEZA PIRI, SHAHRBANOU ORYAN, BAHRAM SOLTANI, and M.R. ZARINDAST, “EFFECTS OF α1- AND α2-ADRENOCEPTOR AGONIST AND ANTAGONIST IN THE DORSAL HIPPOCAMPUS ON CANNABINOID STATE-DEPENDENT MEMORY,” JOURNAL OF ANIMAL BIOLOGY, vol. 1, no. 4, pp. 59–67, 2009, [Online]. Available: https://sid.ir/paper/176691/en

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