INVESTIGATION OF INTRON 3 POLYMORPHISM OF P53 IN BREAST CANCER PATIENTS IN ISFAHAN

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FAGHANI M.; MOHAMMAD GHASEMI F.; NASIRI E.; NIKBAKHT M.

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Journal: Avicenna Journal of Clinical Medicine Year:2009 | Volume:16 | Issue:3 (SN 53) Page(s): 16-20

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Title

INVESTIGATION OF INTRON 3 POLYMORPHISM OF P53 IN BREAST CANCER PATIENTS IN ISFAHAN

Author(s)

FAGHANI M. | MOHAMMAD GHASEMI F. | NASIRI E. | NIKBAKHT M. | Issue Writer Certificate

Keywords

BREAST NEOPLASMSQ3

INTRON 3Q2

P53 TUMOR SUPPRESSOR GENEQ3

POLYMORPHISMQ3

Abstract

Introduction & Objective: Genetic agents play important roles in developing of cancers.Mutations and POLYMORPHISM affects on p53 protein function in suppressing tumor. We aimed to investigate the INTRON 3 POLYMORPHISM of p53 in Isfahanian breast invasive ductal carcinoma.Materials & Methods: We undertook a case-control study on 192 controls and 192 patients with breast invasive ductal carcinoma from Isfahan. p53 INTRON 3 genotypes were identified using allele-specific PCR. The X2-test was used to assess the statistical significance of the data.Results: In control samples, the genotype distribution for p53 INTRON 3 POLYMORPHISMs was 57.3% and 42.7% for the A1/A2 and A1/A1 genotypes, respectively. In the cancer group, 85.4% of the cases were A1/A2 and 14.6%were A1/A1. The differences in the distribution of the p53 INTRON 3 POLYMORPHISM between the cases and controls were statistically significant (P<0.001).Conclusion: Our findings indicated that p53 INTRON 3 POLYMORPHISM probably is a genetic predisposing factor for breast invasive ductal carcinoma development in Isfahanian specimens.

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APA: Copy

FAGHANI, M., MOHAMMAD GHASEMI, F., NASIRI, E., & NIKBAKHT, M.. (2009). INVESTIGATION OF INTRON 3 POLYMORPHISM OF P53 IN BREAST CANCER PATIENTS IN ISFAHAN. AVICENNA JOURNAL OF CLINICAL MEDICINE (SCIENTIFIC JOURNAL OF HAMADAN UNIVERSITY OF MEDICAL SCIENCES AND HEALTH SERVICES), 16(3 (SN 53)), 16-20. SID. https://sid.ir/paper/17690/en

Vancouver: Copy

FAGHANI M., MOHAMMAD GHASEMI F., NASIRI E., NIKBAKHT M.. INVESTIGATION OF INTRON 3 POLYMORPHISM OF P53 IN BREAST CANCER PATIENTS IN ISFAHAN. AVICENNA JOURNAL OF CLINICAL MEDICINE (SCIENTIFIC JOURNAL OF HAMADAN UNIVERSITY OF MEDICAL SCIENCES AND HEALTH SERVICES)[Internet]. 2009;16(3 (SN 53)):16-20. Available from: https://sid.ir/paper/17690/en

IEEE: Copy

M. FAGHANI, F. MOHAMMAD GHASEMI, E. NASIRI, and M. NIKBAKHT, “INVESTIGATION OF INTRON 3 POLYMORPHISM OF P53 IN BREAST CANCER PATIENTS IN ISFAHAN,” AVICENNA JOURNAL OF CLINICAL MEDICINE (SCIENTIFIC JOURNAL OF HAMADAN UNIVERSITY OF MEDICAL SCIENCES AND HEALTH SERVICES), vol. 16, no. 3 (SN 53), pp. 16–20, 2009, [Online]. Available: https://sid.ir/paper/17690/en

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