THE EFFECT OF CHRONIC ORAL ADMINISTRATION OF WITHANIA SOMNIFERA ROOT ON LEARNING AND MEMORY IN DIABETIC RATS USING PASSIVE AVOIDANCE TEST

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ROUGHANI M.; BALUCHNEJADMOJARAD TOURANDOKHT; KHALILI M.; MAHDAVI SALIMI S.F.

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Journal: Avicenna Journal of Clinical Medicine Year:2006 | Volume:13 | Issue:2 (SN 40) Page(s): 10-17

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Title

THE EFFECT OF CHRONIC ORAL ADMINISTRATION OF WITHANIA SOMNIFERA ROOT ON LEARNING AND MEMORY IN DIABETIC RATS USING PASSIVE AVOIDANCE TEST

Author(s)

ROUGHANI M. | BALUCHNEJADMOJARAD TOURANDOKHT | KHALILI M. | MAHDAVI SALIMI S.F. | Issue Writer Certificate

Keywords

ASHWAGANDHAQ3

DIABETES MELLITUSQ3

LEARNINGQ3

MEMORYQ2

PASSIVE AVOIDANCE TEST RATSQ3

STREPTOZOTOCINQ3

Abstract

Introduction & Objective: DIABETES MELLITUS (especially type I) is accompanied with disturbances in LEARNING, MEMORY, and cognitive skills in the human society and experimental animals. Considering the potential anti-diabetic effect of the medicinal plant Withania somnifera (ASHWAGANDHA) and the augmenting effect of its consumption on the MEMORY and mental health, this study was conducted to evaluate the effect of chronic oral administration of ASHWAGANDHA root on LEARNING and MEMORY in diabetic rats using passive avoidance test.Materials & Methods: For this purpose, male Wistar diabetic rats were randomly divided into control, ASHWAGANDHA-treated control, diabetic, and ASHWAGANDHA-treated diabetic groups. ASHWAGANDHA treatment continued for 1 to 2 months. For induction of diabetes, STREPTOZOTOCIN was injected i.p. at a single dose of 60 mg/kg. Serum glucose level was determined before the study and at 4th and 8th weeks after the experiment. In addition, for evaluation of LEARNING and MEMORY, initial latency (IL) and step-through latency (STL) were determined after 1 and 2 months using passive avoidance test.Results: It was found that one- and two-month administration of ASHWAGANDHA root at a weight ratio of 1/15 has not any significant hypoglycemic effect in treated control and diabetic groups. Furthermore, there was a significant increase (p<0.05) in IL in diabetic and ASHWAGANDHA-treated diabetic groups after two months compared to control group. In this respect, there was no significant difference between diabetic and ASHWAGANDHA-treated diabetic groups. In addition, STL significantly increased in ASHWAGANDHA-treated control group after 1 (p<0.01) and 2 (p<0.05) month in comparison to control group. On the other hand, STL significantly decreased (p<0.05) in diabetic group and significantly increased (p<0.05) in ASHWAGANDHA-treated diabetic group as compared to control group after two months.Conclusion: In summary, chronic oral administration of ASHWAGANDHA root could enhance the consolidation and recall capability of stored information in control and diabetic animals.

Cites

EFFECT OF RESVERATROL FLAVONOID ON LEARNING AND MEMORY IN PASSIVE AVOIDANCE AND Y MAZE IN DIABETIC RAT

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APA: Copy

ROUGHANI, M., BALUCHNEJADMOJARAD, TOURANDOKHT, KHALILI, M., & MAHDAVI SALIMI, S.F.. (2006). THE EFFECT OF CHRONIC ORAL ADMINISTRATION OF WITHANIA SOMNIFERA ROOT ON LEARNING AND MEMORY IN DIABETIC RATS USING PASSIVE AVOIDANCE TEST. AVICENNA JOURNAL OF CLINICAL MEDICINE (SCIENTIFIC JOURNAL OF HAMADAN UNIVERSITY OF MEDICAL SCIENCES AND HEALTH SERVICES), 13(2 (SN 40)), 10-17. SID. https://sid.ir/paper/17707/en

Vancouver: Copy

ROUGHANI M., BALUCHNEJADMOJARAD TOURANDOKHT, KHALILI M., MAHDAVI SALIMI S.F.. THE EFFECT OF CHRONIC ORAL ADMINISTRATION OF WITHANIA SOMNIFERA ROOT ON LEARNING AND MEMORY IN DIABETIC RATS USING PASSIVE AVOIDANCE TEST. AVICENNA JOURNAL OF CLINICAL MEDICINE (SCIENTIFIC JOURNAL OF HAMADAN UNIVERSITY OF MEDICAL SCIENCES AND HEALTH SERVICES)[Internet]. 2006;13(2 (SN 40)):10-17. Available from: https://sid.ir/paper/17707/en

IEEE: Copy

M. ROUGHANI, TOURANDOKHT BALUCHNEJADMOJARAD, M. KHALILI, and S.F. MAHDAVI SALIMI, “THE EFFECT OF CHRONIC ORAL ADMINISTRATION OF WITHANIA SOMNIFERA ROOT ON LEARNING AND MEMORY IN DIABETIC RATS USING PASSIVE AVOIDANCE TEST,” AVICENNA JOURNAL OF CLINICAL MEDICINE (SCIENTIFIC JOURNAL OF HAMADAN UNIVERSITY OF MEDICAL SCIENCES AND HEALTH SERVICES), vol. 13, no. 2 (SN 40), pp. 10–17, 2006, [Online]. Available: https://sid.ir/paper/17707/en

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