INVESTIGATION OF HOMOCYSTEIN PLASMA LEVEL IN CHOLESTATIC RAT AND ITS EFFECT ON NITRIC OXIDE SECRETION IN LIVER

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MIRZAEI N.; DEHPOUR A.R.

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Journal: Avicenna Journal of Clinical Medicine Year:2005 | Volume:12 | Issue:1 (SN 35) Page(s): 25-34

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Title

INVESTIGATION OF HOMOCYSTEIN PLASMA LEVEL IN CHOLESTATIC RAT AND ITS EFFECT ON NITRIC OXIDE SECRETION IN LIVER

Author(s)

MIRZAEI N. | DEHPOUR A.R. | Issue Writer Certificate

Keywords

CHOLESTASISQ3

HOMOCYSTEINQ3

NITRIC OXIDEQ3

Abstract

Homocystein (Hcy), one of the thio-amino acid is known as a risk factor in some cardiovascular diseases with releasing O2 radical. It has also been reported that; there is oxidative stress effects of Hcy in CHOLESTASIS. The aim of this study is to determine plasma Hcy alteration and NITRIC OXIDE (NO) .in liver and its effects on pathologic dysfunction.In this study, 150 Spraque - Dawley male rats with 200±20g body weight were used in the experiments and they were randomly divided in three control, SHAM and bile duct ligation (BDL) groups (n=10-12). In 7th, 14th, 21st and 28th days CHOLESTASIS was observed in BDL group, the animal were anesthetized with ether and then blood samples were taken from heart directly and analysed for cystein , methionine by HPLC and HPLC-UV. Two hours before blood sampling, 40 and 100 mg/kg methionine were injected (I.P).All data are expressed as mean±SEM. Statistical evaluation of data performed by SPSSs of ware using analysis of variance (ANOVA) followed by post hoc test. P-values less than 0.05 were considered statistically significant. The results suggest that billirubin and hepatic enzymes were significantly elevated in BDL rats compared with SHAM and controls (P<0.05). HOMOCYSTEIN concentration was significantly rised in 14th day in BDLgroup (P<0.05). The plasma cystein and methionine level were significantly elevated in BDLrats compared with SHAM and control groups (p=0.01). Plasma nitrate / nitrite ratio were significantly increased in BDL rats compared with SHAM and control rats (P<0.05). With these data we suppose that some of the systemic oxidative stresses in BD Lrat model of CHOLESTASIS contribute possibly through NO-dependent mechanisms disorders.

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APA: Copy

MIRZAEI, N., & DEHPOUR, A.R.. (2005). INVESTIGATION OF HOMOCYSTEIN PLASMA LEVEL IN CHOLESTATIC RAT AND ITS EFFECT ON NITRIC OXIDE SECRETION IN LIVER. AVICENNA JOURNAL OF CLINICAL MEDICINE (SCIENTIFIC JOURNAL OF HAMADAN UNIVERSITY OF MEDICAL SCIENCES AND HEALTH SERVICES), 12(1 (SN 35)), 25-34. SID. https://sid.ir/paper/17838/en

Vancouver: Copy

MIRZAEI N., DEHPOUR A.R.. INVESTIGATION OF HOMOCYSTEIN PLASMA LEVEL IN CHOLESTATIC RAT AND ITS EFFECT ON NITRIC OXIDE SECRETION IN LIVER. AVICENNA JOURNAL OF CLINICAL MEDICINE (SCIENTIFIC JOURNAL OF HAMADAN UNIVERSITY OF MEDICAL SCIENCES AND HEALTH SERVICES)[Internet]. 2005;12(1 (SN 35)):25-34. Available from: https://sid.ir/paper/17838/en

IEEE: Copy

N. MIRZAEI, and A.R. DEHPOUR, “INVESTIGATION OF HOMOCYSTEIN PLASMA LEVEL IN CHOLESTATIC RAT AND ITS EFFECT ON NITRIC OXIDE SECRETION IN LIVER,” AVICENNA JOURNAL OF CLINICAL MEDICINE (SCIENTIFIC JOURNAL OF HAMADAN UNIVERSITY OF MEDICAL SCIENCES AND HEALTH SERVICES), vol. 12, no. 1 (SN 35), pp. 25–34, 2005, [Online]. Available: https://sid.ir/paper/17838/en

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