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Title

DESIGN AND SYNTHESIS OF 1-BENZYL-3-((2, 3-DIOXOINDOLIN-1-YL)METHYL) PYRIDINIUM BROMIDE AND EVALUATION OF ACETYL-AND BUTYRYL-CHOLINESTERASE ACTIVITY AS NOVEL ANTI ALZHEIMER DERIVATIVES

Pages

  89-99

Abstract

 In this paper, the synthesis of novel 1-benzyl-3-((2, 3-dioxoindolin-1-yl) methyl) pyridinium bromide is reported. The products were synthesized in two steps from ISATIN and 3-(chloromethyl) pyridine or 4-(chloromethyl) pyridine derivatives in basic conditions. The inhibition activity of the products was studied against acetyl- and BUTYRYL-CHOLINESTERASE. The results showed that, 4-pyridine derivatives had higher activities than 3-pyridine derivatives. In addition, among 4-pyridine derivatives, the best activities were related to 5a, 5b, 5c, 5g, and 5h, while 5b had the highest inhibition activity by IC50 = 1.00 mM, which could be applied in the treatment of ALZHEIMER DESEASE.

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    APA: Copy

    MOGHANLOU, M., & MIRZA, B.. (2018). DESIGN AND SYNTHESIS OF 1-BENZYL-3-((2, 3-DIOXOINDOLIN-1-YL)METHYL) PYRIDINIUM BROMIDE AND EVALUATION OF ACETYL-AND BUTYRYL-CHOLINESTERASE ACTIVITY AS NOVEL ANTI ALZHEIMER DERIVATIVES. JOURNAL OF APPLIED RESEARCHES IN CHEMISTRY (JARC), 11(4 ), 89-99. SID. https://sid.ir/paper/179993/en

    Vancouver: Copy

    MOGHANLOU M., MIRZA B.. DESIGN AND SYNTHESIS OF 1-BENZYL-3-((2, 3-DIOXOINDOLIN-1-YL)METHYL) PYRIDINIUM BROMIDE AND EVALUATION OF ACETYL-AND BUTYRYL-CHOLINESTERASE ACTIVITY AS NOVEL ANTI ALZHEIMER DERIVATIVES. JOURNAL OF APPLIED RESEARCHES IN CHEMISTRY (JARC)[Internet]. 2018;11(4 ):89-99. Available from: https://sid.ir/paper/179993/en

    IEEE: Copy

    M. MOGHANLOU, and B. MIRZA, “DESIGN AND SYNTHESIS OF 1-BENZYL-3-((2, 3-DIOXOINDOLIN-1-YL)METHYL) PYRIDINIUM BROMIDE AND EVALUATION OF ACETYL-AND BUTYRYL-CHOLINESTERASE ACTIVITY AS NOVEL ANTI ALZHEIMER DERIVATIVES,” JOURNAL OF APPLIED RESEARCHES IN CHEMISTRY (JARC), vol. 11, no. 4 , pp. 89–99, 2018, [Online]. Available: https://sid.ir/paper/179993/en

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