STUDY OF RELEASE RATE OF PODOPHYLLOTOXIN IN CHITOSAN HYDROGEL

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SEDAGHAT S.; ESLAMI M.

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Journal: Journal of Applied Research in Chemistry Year:2018 | Volume:11 | Issue:4 Page(s): 71-76

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Information Journal Paper

Title

STUDY OF RELEASE RATE OF PODOPHYLLOTOXIN IN CHITOSAN HYDROGEL

Author(s)

SEDAGHAT S. | ESLAMI M. | Issue Writer Certificate

Keywords

SOLVENT CASTINGQ1

CHITOSANQ1

PODOPHYLLOTOXINQ1

DRUG DELIVERY CARRIERQ1

Abstract

In biological fluids, CHITOSAN hydrogel has become a potential candidate for carriers of bioactive molecules and controlled release of drugs in their swollen state. The prepared film of cross-linked CHITOSAN utilized as a medium for delivery of PODOPHYLLOTOXIN in skin diseases. The drug delivery systems can reduce side effects of toxins and provide a high concentration of drug at the site. Physicochemical properties of prepared film, such as swelling behavior and release rate were studied. Some parameters have influenced on hydrogel swelling including cross linker concentration, temperature, and pH. The prepared hydrogel shows maximum swelling at the lowest PH. Hydrogel films with 15% glutaraldehyde as a cross linker have good behavior for drug release. Formulations prepared from CHITOSAN and acryl amide have good behavior, but the concentration of cross linker has a negative effect. Drug release profile in this film follows the first rate model.

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APA: Copy

SEDAGHAT, S., & ESLAMI, M.. (2018). STUDY OF RELEASE RATE OF PODOPHYLLOTOXIN IN CHITOSAN HYDROGEL. JOURNAL OF APPLIED RESEARCHES IN CHEMISTRY (JARC), 11(4 ), 71-76. SID. https://sid.ir/paper/179994/en

Vancouver: Copy

SEDAGHAT S., ESLAMI M.. STUDY OF RELEASE RATE OF PODOPHYLLOTOXIN IN CHITOSAN HYDROGEL. JOURNAL OF APPLIED RESEARCHES IN CHEMISTRY (JARC)[Internet]. 2018;11(4 ):71-76. Available from: https://sid.ir/paper/179994/en

IEEE: Copy

S. SEDAGHAT, and M. ESLAMI, “STUDY OF RELEASE RATE OF PODOPHYLLOTOXIN IN CHITOSAN HYDROGEL,” JOURNAL OF APPLIED RESEARCHES IN CHEMISTRY (JARC), vol. 11, no. 4 , pp. 71–76, 2018, [Online]. Available: https://sid.ir/paper/179994/en

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