STUDY OF BIOLOGICAL ACTIVITY OF SULFONAMIDE-SCHIFF BASES COMPOUNDSCOATING WITH ZINC (II) AND COPPER(II) MICRO OXIDES

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TAHRIRI MOZHGAN; TABATABAEE MASOUMEH; YOUSEFI MOHAMMAD; MEHRANI KHEIROLLAH; DEHGHANI ASHKEZARI MAHMOOD

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Journal: Journal of Applied Research in Chemistry Year:2018 | Volume:12 | Issue:1 Page(s): 27-38

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Title

STUDY OF BIOLOGICAL ACTIVITY OF SULFONAMIDE-SCHIFF BASES COMPOUNDSCOATING WITH ZINC (II) AND COPPER(II) MICRO OXIDES

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Keywords

SULFONYL CHLORIDEQ1

SCHIFF BASEQ1

ANTIBACTERIAL ACTIVITYQ1

MICRO PARTICLES ZINC OXIDEQ1

MICRO PARTICLES COPPER OXIDEQ1

Abstract

In this study, two sulfonamide – SCHIFF BASE compounds "N'-(2-hydroxy-3-methoxybenzylidene)-4-methylbenzenesulfonohydrazide and 1, 2-bis(2-hydrxy-3-methoxy-benzylidenehydrazine) (1) and N'-(2-hydroxy-3-methoxybenzylidene)-4-nitrobenzenesulfonohydrazide and 1, 2-bis(2-hydrxy-3-methoxy-benzylidenehydrazine)(2)" were synthesized by SULFONYL CHLORIDE and SCHIFF BASE compounds. Copper and zinc oxides were coated bysynthesized compounds and were tested for ANTIBACTERIAL ACTIVITY. All compounds were identified by NMR and FTIRspectra, X-ray diffraction (XRD), and elemental analysis. Scanning Electron Microscope SEM was used for themorphology of micro metal oxides before and after coating with Sulfonamide-Schiff bases compounds. Accordingly, ANTIBACTERIAL ACTIVITY of compounds against Gram-positive bacteria (Staphylococcus epidermidis and Staphylococcussaprophyticus) and Gram-negative bacteria (Proteus mirabilis) were tested. It should be noted that both have highantimicrobial activities. The result of the study shows that the antibacterial activities of the synthesized sulfonamideschiffbases against gram positive and gram negative bacteria decrease after coating on micro metal oxides. It is alsoworth mentioning that Ampicilin and Penicilin have been utilized as two standard medicines for investigating theantibacterial activities.

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APA: Copy

TAHRIRI, MOZHGAN, TABATABAEE, MASOUMEH, YOUSEFI, MOHAMMAD, MEHRANI, KHEIROLLAH, & DEHGHANI ASHKEZARI, MAHMOOD. (2018). STUDY OF BIOLOGICAL ACTIVITY OF SULFONAMIDE-SCHIFF BASES COMPOUNDSCOATING WITH ZINC (II) AND COPPER(II) MICRO OXIDES. JOURNAL OF APPLIED RESEARCHES IN CHEMISTRY (JARC), 12(1 ), 27-38. SID. https://sid.ir/paper/180103/en

Vancouver: Copy

TAHRIRI MOZHGAN, TABATABAEE MASOUMEH, YOUSEFI MOHAMMAD, MEHRANI KHEIROLLAH, DEHGHANI ASHKEZARI MAHMOOD. STUDY OF BIOLOGICAL ACTIVITY OF SULFONAMIDE-SCHIFF BASES COMPOUNDSCOATING WITH ZINC (II) AND COPPER(II) MICRO OXIDES. JOURNAL OF APPLIED RESEARCHES IN CHEMISTRY (JARC)[Internet]. 2018;12(1 ):27-38. Available from: https://sid.ir/paper/180103/en

IEEE: Copy

MOZHGAN TAHRIRI, MASOUMEH TABATABAEE, MOHAMMAD YOUSEFI, KHEIROLLAH MEHRANI, and MAHMOOD DEHGHANI ASHKEZARI, “STUDY OF BIOLOGICAL ACTIVITY OF SULFONAMIDE-SCHIFF BASES COMPOUNDSCOATING WITH ZINC (II) AND COPPER(II) MICRO OXIDES,” JOURNAL OF APPLIED RESEARCHES IN CHEMISTRY (JARC), vol. 12, no. 1 , pp. 27–38, 2018, [Online]. Available: https://sid.ir/paper/180103/en

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