SIMULTANEOUS QUANTITATION OF THEOPHYLLINE AND GUAIFENESIN IN SYRUP BY CWT AND DERIVATIVE SPECTROPHOTOMETRY FOR QUALITY CONTROL PURPOSES

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SOHRABI MAHMOUD REZA; ALAEDDINI ENSIEH; JAVANBAKHT MEHRAN; SAREBAN MONIREH; MARANDI PARI

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Journal: Journal of Applied Research in Chemistry Year:2009 | Volume:3 | Issue:9 Page(s): 15-20

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Title

SIMULTANEOUS QUANTITATION OF THEOPHYLLINE AND GUAIFENESIN IN SYRUP BY CWT AND DERIVATIVE SPECTROPHOTOMETRY FOR QUALITY CONTROL PURPOSES

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Keywords

THEOPHYLLINEQ3

GUAIFENESINQ3

CALIBRATIONQ3

DERIVATIVE SPECTROPHOTOMETRYQ3

CONTINUOUS WAVELET TRANSFORMQ3

Abstract

The aim of the present work was to develop a simple and rapid method for determination of THEOPHYLLINE (THP) and GUAIFENESIN (GU) in syrup. Simultaneous analysis THEOPHYLLINE and GUAIFENESIN was carried out by CONTINUOUS WAVELET TRANSFORM (CWT) and DERIVATIVE SPECTROPHOTOMETRY (DS) without involving any preparation operations like chemical separation step or masking. THP, a member of xanthine based alkaloids, which relaxes smooth muscles and relieves bronco spasm, has a stimulant effect on respiration. GU, a mucolytic agent, is used as an expectorant. The use of the mixture of THP and GU in the symptomatic treatment of bronchial asthma and other broncho spastic conditions is well established in pharmaceutical formulations. In the CWT method, the determination was performed at 270.2 nm for THP and at 224.4 nm for GU (for wavelet family coif 5, a=300). In the first-derivative spectrophotometry determination of THP and GU was realized by measurements of amplitudes of derivative spectra corresponding to zero-crossing points of THP and GU at 305 and 242.4 nm, respectively. The proposed procedures were validated by using various synthetic mixtures with high percentage of recovery and good precision. Mean recovery values were found 99.90% and 101.2% for CWT CALIBRATION method and 96% and 98% for DERIVATIVE SPECTROPHOTOMETRY, respectively for determination of THP and GU in synthetic mixtures. Also good agreement between the results obtained using the two procedures was found, which agreed also with the product label.

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APA: Copy

SOHRABI, MAHMOUD REZA, ALAEDDINI, ENSIEH, JAVANBAKHT, MEHRAN, SAREBAN, MONIREH, & MARANDI, PARI. (2009). SIMULTANEOUS QUANTITATION OF THEOPHYLLINE AND GUAIFENESIN IN SYRUP BY CWT AND DERIVATIVE SPECTROPHOTOMETRY FOR QUALITY CONTROL PURPOSES. JOURNAL OF APPLIED RESEARCHES IN CHEMISTRY (JARC), 3(9), 15-20. SID. https://sid.ir/paper/180113/en

Vancouver: Copy

SOHRABI MAHMOUD REZA, ALAEDDINI ENSIEH, JAVANBAKHT MEHRAN, SAREBAN MONIREH, MARANDI PARI. SIMULTANEOUS QUANTITATION OF THEOPHYLLINE AND GUAIFENESIN IN SYRUP BY CWT AND DERIVATIVE SPECTROPHOTOMETRY FOR QUALITY CONTROL PURPOSES. JOURNAL OF APPLIED RESEARCHES IN CHEMISTRY (JARC)[Internet]. 2009;3(9):15-20. Available from: https://sid.ir/paper/180113/en

IEEE: Copy

MAHMOUD REZA SOHRABI, ENSIEH ALAEDDINI, MEHRAN JAVANBAKHT, MONIREH SAREBAN, and PARI MARANDI, “SIMULTANEOUS QUANTITATION OF THEOPHYLLINE AND GUAIFENESIN IN SYRUP BY CWT AND DERIVATIVE SPECTROPHOTOMETRY FOR QUALITY CONTROL PURPOSES,” JOURNAL OF APPLIED RESEARCHES IN CHEMISTRY (JARC), vol. 3, no. 9, pp. 15–20, 2009, [Online]. Available: https://sid.ir/paper/180113/en

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