An efficient one-pot synthesis of 2-iminohexahydroquinazolin-5(6H)-one derivatives with pharmaceutical potential under catalyst-free conditions and antibacterial evaluation

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Mirza Aghayan Maryam; Baie Lashaki Tahmineh

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Journal: Journal of Applied Research in Chemistry Year:2019 | Volume:13 | Issue:2 Page(s): 19-31

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Title

An efficient one-pot synthesis of 2-iminohexahydroquinazolin-5(6H)-one derivatives with pharmaceutical potential under catalyst-free conditions and antibacterial evaluation

Author(s)

Mirza Aghayan Maryam | Baie Lashaki Tahmineh | Issue Writer Certificate

Keywords

2-imino-hexahydroquinazolin-5(6H)-one derivativesQ1

Guanidinium carbonateQ1

Hexahydroxanthene derivativesQ1

Guanidinium chlorideQ1

Antibacterial activityQ1

Abstract

An efficient one-pot method for the synthesis of fused 2-imino-hexahydroquinazolin-5(6H)-one derivatives with pharmaceutical potential from cyclocondensation of dimedone, aldehydes, and Guanidinium carbonate under catalyst-free and environmentally friendly conditions is described. The present method displays several key advantages such as one-pot and catalystfree conditions, high yields, short reaction times, and simple product purification procedure, i. e., simple recrystallization from ethanol. It should be noted that the obtained results also indicated that cyclocondensation of dimedone and aldehydes using Guanidinium chloride in presence of sodium hydrogen carbonate as base led to synthesis of fused 2-imino-hexahydroquinazolin-5(6H)-one derivatives with pharmaceutical potential with high yields, and short reaction times. The obtained results also indicated that cyclocondensation of dimedone and aldehydes in presence of Guanidinium chloride as a promoter led to synthesis of Hexahydroxanthene derivatives with pharmaceutical potential with high yields and short reaction times. In addition, the results of the antibacterial test for some of the hexahydroquinazolin and hexahydroxanthene compounds showed that these compounds had a good activity against a gram-negative bacteria such as Escherichia coli and had the ability to adequately inhibit the growth of bacteria.

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APA: Copy

Mirza Aghayan, Maryam, & Baie Lashaki, Tahmineh. (2019). An efficient one-pot synthesis of 2-iminohexahydroquinazolin-5(6H)-one derivatives with pharmaceutical potential under catalyst-free conditions and antibacterial evaluation. JOURNAL OF APPLIED RESEARCHES IN CHEMISTRY (JARC), 13(2 ), 19-31. SID. https://sid.ir/paper/180257/en

Vancouver: Copy

Mirza Aghayan Maryam, Baie Lashaki Tahmineh. An efficient one-pot synthesis of 2-iminohexahydroquinazolin-5(6H)-one derivatives with pharmaceutical potential under catalyst-free conditions and antibacterial evaluation. JOURNAL OF APPLIED RESEARCHES IN CHEMISTRY (JARC)[Internet]. 2019;13(2 ):19-31. Available from: https://sid.ir/paper/180257/en

IEEE: Copy

Maryam Mirza Aghayan, and Tahmineh Baie Lashaki, “An efficient one-pot synthesis of 2-iminohexahydroquinazolin-5(6H)-one derivatives with pharmaceutical potential under catalyst-free conditions and antibacterial evaluation,” JOURNAL OF APPLIED RESEARCHES IN CHEMISTRY (JARC), vol. 13, no. 2 , pp. 19–31, 2019, [Online]. Available: https://sid.ir/paper/180257/en

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