ELECTROCHEMICAL SENSOR BASED ON MOLECULARLY IMPRINTED POLYMER NANOPARTICLES FOR DETERMINATION OF DIAZEPAM DRUG

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MOTAHARIAN A.; MILANI HOSSEINI M.R.

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Journal: Journal of Applied Research in Chemistry Year:2015 | Volume:9 | Issue:3 Page(s): 51-59

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Title

ELECTROCHEMICAL SENSOR BASED ON MOLECULARLY IMPRINTED POLYMER NANOPARTICLES FOR DETERMINATION OF DIAZEPAM DRUG

Author(s)

MOTAHARIAN A. | MILANI HOSSEINI M.R. | Issue Writer Certificate

Keywords

MOLECULARLY IMPRINTED POLYMERQ2

NANOPARTICLESQ1

ELECTROCHEMICAL SENSORQ1

DIAZEPAMQ1

CARBON PASTE ELECTRODESQ1

Abstract

In this research an ELECTROCHEMICAL SENSOR based on carbon paste (CP) electrode modified by MOLECULARLY IMPRINTED POLYMER (MIP) was prepared for determining of the DIAZEPAM (DZ) drug. MOLECULARLY IMPRINTED POLYMER microparticles were synthesized by precipitation polymerization method and then were used as identification element in construction of the sensor.Also for comparison, the non-imprinted polymer (NIP) particles were synthesized in a similar manner but in absence of DIAZEPAM molecules. SEM images of obtained polymers showed that the MIP particles have dimensions in the range of 100-300 nm. Cyclic voltammetry (CV) and square wave voltammetry (SWV) methods were applied to study the electrochemical behavior and quantitative measurements. The obtained results showed that the MIP-CP electrode have much higher adsorption ability to DIAZEPAM than the NIP-CP electrode. The effect of some parameters affecting on the sensor response, such as electrode composition, extraction conditions, and electrochemical measurements conditions were studied and then calibration curve was drawn.Peak current showed a linear relationship with DIAZEPAM concentration in range of 4.0 × 10-8 to 8.0 × 10-6 mol L-1 and the limit of detection was also equal to 1.94 × 10-8mol L-1. The relative standard deviation for five measurement of 5.0 × 10-7 mol L-1 DIAZEPAM solution was obtained 3.48%. The developed sensor has been successfully used for determinations of DIAZEPAM in human blood serum samples.

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APA: Copy

MOTAHARIAN, A., & MILANI HOSSEINI, M.R.. (2015). ELECTROCHEMICAL SENSOR BASED ON MOLECULARLY IMPRINTED POLYMER NANOPARTICLES FOR DETERMINATION OF DIAZEPAM DRUG. JOURNAL OF APPLIED RESEARCHES IN CHEMISTRY (JARC), 9(3), 51-59. SID. https://sid.ir/paper/180276/en

Vancouver: Copy

MOTAHARIAN A., MILANI HOSSEINI M.R.. ELECTROCHEMICAL SENSOR BASED ON MOLECULARLY IMPRINTED POLYMER NANOPARTICLES FOR DETERMINATION OF DIAZEPAM DRUG. JOURNAL OF APPLIED RESEARCHES IN CHEMISTRY (JARC)[Internet]. 2015;9(3):51-59. Available from: https://sid.ir/paper/180276/en

IEEE: Copy

A. MOTAHARIAN, and M.R. MILANI HOSSEINI, “ELECTROCHEMICAL SENSOR BASED ON MOLECULARLY IMPRINTED POLYMER NANOPARTICLES FOR DETERMINATION OF DIAZEPAM DRUG,” JOURNAL OF APPLIED RESEARCHES IN CHEMISTRY (JARC), vol. 9, no. 3, pp. 51–59, 2015, [Online]. Available: https://sid.ir/paper/180276/en

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