Determination of atorvastatin tablet samples by dispersive liquid-liquid microextraction based on solidification of organic drop and central composite design optimization using high-performance liquid chromatography

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Shiri Fereshteh; HASHEMI BESHARE; Fazlipour Iman; NEJATI YAZDINEJAD MASSOUD

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Journal: Journal of Applied Research in Chemistry Year:2018 | Volume:12 | Issue:3 Page(s): 79-86

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Title

Determination of atorvastatin tablet samples by dispersive liquid-liquid microextraction based on solidification of organic drop and central composite design optimization using high-performance liquid chromatography

Author(s)

Shiri Fereshteh | HASHEMI BESHARE | Fazlipour Iman | NEJATI YAZDINEJAD MASSOUD | Issue Writer Certificate

Keywords

AtorvastatinQ1

dispersive liquid-liquid microextractionQ1

experimental designQ1

Abstract

A simple, rapid, and inexpensive dispersive liquid-liquid microextraction based on solidification of organic drop (DLLME-SFO) combined with high-performance liquid chromatography was developed for the extraction and determination of trace levels of Atorvastatin (ATV) in tablet. Effect of variables such as extracting and dispersive solvent volume and pH were investigated simultaneously using experimental design. Under the optimum conditions, the calibration graph was linear in the range of 1-200 μ g L-1 with the detection limit of 0. 3 μ g L-1. The optimized method revealed a good precision with relative standard deviation (RSD) of 2. 2 %. The performance of the method was evaluated for extraction and determination of ATV in tablet sample. The results of this study revealed that the proposed method gives high extraction efficiency and low LOD. The most important advantage of this technique is that the use of large sample volumes and toxic organic solvents have been omitted.

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APA: Copy

Shiri, Fereshteh, HASHEMI, BESHARE, Fazlipour, Iman, & NEJATI YAZDINEJAD, MASSOUD. (2018). Determination of atorvastatin tablet samples by dispersive liquid-liquid microextraction based on solidification of organic drop and central composite design optimization using high-performance liquid chromatography. JOURNAL OF APPLIED RESEARCHES IN CHEMISTRY (JARC), 12(3 ), 79-86. SID. https://sid.ir/paper/180285/en

Vancouver: Copy

Shiri Fereshteh, HASHEMI BESHARE, Fazlipour Iman, NEJATI YAZDINEJAD MASSOUD. Determination of atorvastatin tablet samples by dispersive liquid-liquid microextraction based on solidification of organic drop and central composite design optimization using high-performance liquid chromatography. JOURNAL OF APPLIED RESEARCHES IN CHEMISTRY (JARC)[Internet]. 2018;12(3 ):79-86. Available from: https://sid.ir/paper/180285/en

IEEE: Copy

Fereshteh Shiri, BESHARE HASHEMI, Iman Fazlipour, and MASSOUD NEJATI YAZDINEJAD, “Determination of atorvastatin tablet samples by dispersive liquid-liquid microextraction based on solidification of organic drop and central composite design optimization using high-performance liquid chromatography,” JOURNAL OF APPLIED RESEARCHES IN CHEMISTRY (JARC), vol. 12, no. 3 , pp. 79–86, 2018, [Online]. Available: https://sid.ir/paper/180285/en

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