Design of a drug intelligent carrier based on carboxymethyl cellulose-acrylamide as a closed loop system in drug delivery and kinetic study of insulin release

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

Vasheghani Farahani Bahman; Zolghadr Leila; GHASEMZADEH HOSSEIN

Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: Journal of Applied Research in Chemistry Year:2018 | Volume:12 | Issue:3 Page(s): 47-56

Download Full-Text

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Persian Verion

View:

887

Download:

Cites:

Information Journal Paper

Title

Design of a drug intelligent carrier based on carboxymethyl cellulose-acrylamide as a closed loop system in drug delivery and kinetic study of insulin release

Author(s)

Vasheghani Farahani Bahman | Zolghadr Leila | GHASEMZADEH HOSSEIN | Issue Writer Certificate

Keywords

glucose oxidaseQ1

intelligent hydro gelQ1

kinetic studyQ1

carboxymethyl celluloseQ1

closed-LoopQ1

Abstract

The present investigation was aimed to develop an intelligent closed-Loop insulin delivery system based on carboxymethyl cellulose-g-polyacrylamide (CMC-g-PAAm) hydro gel. To control the release of insulin in response to the concentration of glucose, glucose oxidase (GOx) was immobilized in the hydro gel. The hydro gels were prepared by polymerization of AAm in the presence of CMC via a free radical polymerization method. Fourier-transform infrared spectroscopy (FTIR), thermo gravimetric analysis (TGA/DTG), and scanning electron microscope (SEM) were used to characterize the structure of the insulin loaded hydro gels. The sensitivity of the intelligent drug carrier to glucose concentration was investigated by UV-Vis Spectroscopy at 280nm. Optimization of the hydro gels loading characteristics was studied by full factorial design. Finally, insulin release from the synthesized drug delivery system was investigated by various kinetic models.

Cites

No record.

References

No record.

Cite

APA: Copy

Vasheghani Farahani, Bahman, Zolghadr, Leila, & GHASEMZADEH, HOSSEIN. (2018). Design of a drug intelligent carrier based on carboxymethyl cellulose-acrylamide as a closed loop system in drug delivery and kinetic study of insulin release. JOURNAL OF APPLIED RESEARCHES IN CHEMISTRY (JARC), 12(3 ), 47-56. SID. https://sid.ir/paper/180289/en

Vancouver: Copy

Vasheghani Farahani Bahman, Zolghadr Leila, GHASEMZADEH HOSSEIN. Design of a drug intelligent carrier based on carboxymethyl cellulose-acrylamide as a closed loop system in drug delivery and kinetic study of insulin release. JOURNAL OF APPLIED RESEARCHES IN CHEMISTRY (JARC)[Internet]. 2018;12(3 ):47-56. Available from: https://sid.ir/paper/180289/en

IEEE: Copy

Bahman Vasheghani Farahani, Leila Zolghadr, and HOSSEIN GHASEMZADEH, “Design of a drug intelligent carrier based on carboxymethyl cellulose-acrylamide as a closed loop system in drug delivery and kinetic study of insulin release,” JOURNAL OF APPLIED RESEARCHES IN CHEMISTRY (JARC), vol. 12, no. 3 , pp. 47–56, 2018, [Online]. Available: https://sid.ir/paper/180289/en

Related Journal Papers