THE PATTERN OF ANTIBIOTIC RESISTANCE AND METALLOBETALACTAMASE PRODUCTION IN PSEUDOMONAS AERUGINOSA ISOLATES FROM CLINICAL SPECIMENS IN DR GANJAVIAN HOSPITAL'S DEZFUL

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DEYHAM B.; BASIKHASTAH M.

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Journal Paper

Paper Information

Journal: JOURNAL OF MICROBIAL BIOTECHNOLOGY Year:2012 | Volume:4 | Issue:14 Page(s): 21-28

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Title

THE PATTERN OF ANTIBIOTIC RESISTANCE AND METALLOBETALACTAMASE PRODUCTION IN PSEUDOMONAS AERUGINOSA ISOLATES FROM CLINICAL SPECIMENS IN DR GANJAVIAN HOSPITAL'S DEZFUL

Author(s)

DEYHAM B. | BASIKHASTAH M. | Issue Writer Certificate

Keywords

PSEUDOMONASE AERUGINOSAQ2

METALLOBETALACTAMASEQ2

E-TESTQ2

CARBAPNEMQ2

Abstract

Background and Objective: Antibiotic resistance which is different in Gram-negative bacteria is increasingly growing up. Pseudomonas aeruginosa is a major cause of serious bacterial infections. METALLOBETALACTAMASE (MBL) enzyme plays an important role in developing resistance to different antimicrobial agents, especially betalactams and carbapenems. In this study, it is aimed to determine antibiotic susceptibility pattern in isolated PSEUDOMONASE AERUGINOSA in an educational hospital Dezful and to investigate phenotypic frequency of MBL.Materials and Methods: A total of 150 isolates of Pseudomonas eaeruginosa from various specimens included 72 samples of urine cultures, 55 Tracheal cultures, 12 blood cultures and 11 wound cultures, were subjected to susceptibility testing against various antibiotics by disc diffusion test (Kirby-Bauer method) according to CLSI guidelines. MBL producing isolates were recognized by E- test strip method. Statistical analysis of the findings was done by SPSS-18 software, and the chi-square test was run.Results: It was found that out of the 150 strains, 27(18%) and 22(14.7 %) were non susceptible to imipenem and meropenem, respectively. Isolates showed the highest antibiotic resistance to Ceftriaxone (41.3%) and ceftazidime (28.7%). It was found that 21(14%) isolates were MBL producers confirmed by E-TEST strip method. The highest frequency of isolates of positive phenotype was in pulmonary secretions (23.6%).Conclusion: Due to the high resistance of Pseudomonas aeruginosa isolates producing MBL enzymes to multiple antibiotics; development of such resistance is a concern in hospitals. So to prevent the spread of infectious diseases, the diagnosis of MBL-producing isolates is recommended.

Cites

FREQUENCY OF PLASMID-MEDIATED QUINOLONE RESISTANCE GENES AMONG CLINICAL ISOLATES OF PSEUDOMONAS AERUGINOSA IN KERMAN, IRAN

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APA: Copy

DEYHAM, B., & BASIKHASTAH, M.. (2012). THE PATTERN OF ANTIBIOTIC RESISTANCE AND METALLOBETALACTAMASE PRODUCTION IN PSEUDOMONAS AERUGINOSA ISOLATES FROM CLINICAL SPECIMENS IN DR GANJAVIAN HOSPITAL'S DEZFUL. JOURNAL OF MICROBIAL BIOTECHNOLOGY, 4(14), 21-28. SID. https://sid.ir/paper/181428/en

Vancouver: Copy

DEYHAM B., BASIKHASTAH M.. THE PATTERN OF ANTIBIOTIC RESISTANCE AND METALLOBETALACTAMASE PRODUCTION IN PSEUDOMONAS AERUGINOSA ISOLATES FROM CLINICAL SPECIMENS IN DR GANJAVIAN HOSPITAL'S DEZFUL. JOURNAL OF MICROBIAL BIOTECHNOLOGY[Internet]. 2012;4(14):21-28. Available from: https://sid.ir/paper/181428/en

IEEE: Copy

B. DEYHAM, and M. BASIKHASTAH, “THE PATTERN OF ANTIBIOTIC RESISTANCE AND METALLOBETALACTAMASE PRODUCTION IN PSEUDOMONAS AERUGINOSA ISOLATES FROM CLINICAL SPECIMENS IN DR GANJAVIAN HOSPITAL'S DEZFUL,” JOURNAL OF MICROBIAL BIOTECHNOLOGY, vol. 4, no. 14, pp. 21–28, 2012, [Online]. Available: https://sid.ir/paper/181428/en

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