SODIUM VALPORATE IN THE PROPHYLACTIC TREATMENT OF MIGRAINE; COMPARING LOW AND HIGH DOSE

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FARHANI A.A.; FARIVAR A.A.; VALAEI NASER

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Journal: Researcher Bulletin of Medical Sciences Year:2001 | Volume:6 | Issue:4 (24) Page(s): 335-338

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Title

SODIUM VALPORATE IN THE PROPHYLACTIC TREATMENT OF MIGRAINE; COMPARING LOW AND HIGH DOSE

Author(s)

FARHANI A.A. | FARIVAR A.A. | VALAEI NASER | Issue Writer Certificate

Keywords

SODIUM VALPORATEQ3

PROPHYLACTIC TREATMENT OF MIGRAINEQ4

Abstract

Background: Migraine is a common debilitating familial disorder that is manifested by unilateral pulsatile periodic headache. Its prevalence is under discussion. Regarding the controversies arisen about the prophylactic dosage of SODIUM VALPORATE, the present study was carried out over the patients referring to Loghman Hakim hospital in 2000 to compare low and high dose of SODIUM VALPORATE. Materials and methods: 60 patients had been selected for this clinical trial of cross-over type. Migraine was diagnosed according to the criteria of International Association of Headache and its severity was described as mild, moderate, and severe. Patients were randomly distributed in two groups of case (receiving 400 mg/d) and control (receiving 1000mg/d). After 8 weeks, groups were exchanged. Drug effects on headache severity, duration, and frequency was recorded. Finally, results were analyzed. Results: 60 patients, including 73.3% females and 26.7% males with mean age of 27.l±8.6 yrs had entered this study. The frequency of headache was 3.43±1.03 attacks each month before the therapy, and the duration was 12-24 hrs in 52% of the patients.22% had reported moderate headache, whereas the remaining 78% had been suffering from severe headache. 6 patients of the control group have missed our study due to drug intolerance. Following the treatment, the frequency of headache was reported 1.29±0.71 and 0.33±0.51 attacks/month in the control and case group, respectively (p<0.0001). 63% of the patients receiving 400 mg/d SODIUM VALPORATE have experienced headache periods of less than 12 hrs, but longer periods (greater than 12 hrs) in case of receiving 1000 mg/d. Conclusion: SODIUM VALPORATE has better prophylactic out come with lesser side effects if prescribed at the dosage of 400mg/d, however, attacks are exist via this dosage, so further studies are highly recommended.

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APA: Copy

FARHANI, A.A., FARIVAR, A.A., & VALAEI, NASER. (2001). SODIUM VALPORATE IN THE PROPHYLACTIC TREATMENT OF MIGRAINE; COMPARING LOW AND HIGH DOSE. RESEARCHER BULLETIN OF MEDICAL SCIENCES (PEJOUHANDEH), 6(4 (24)), 335-338. SID. https://sid.ir/paper/18285/en

Vancouver: Copy

FARHANI A.A., FARIVAR A.A., VALAEI NASER. SODIUM VALPORATE IN THE PROPHYLACTIC TREATMENT OF MIGRAINE; COMPARING LOW AND HIGH DOSE. RESEARCHER BULLETIN OF MEDICAL SCIENCES (PEJOUHANDEH)[Internet]. 2001;6(4 (24)):335-338. Available from: https://sid.ir/paper/18285/en

IEEE: Copy

A.A. FARHANI, A.A. FARIVAR, and NASER VALAEI, “SODIUM VALPORATE IN THE PROPHYLACTIC TREATMENT OF MIGRAINE; COMPARING LOW AND HIGH DOSE,” RESEARCHER BULLETIN OF MEDICAL SCIENCES (PEJOUHANDEH), vol. 6, no. 4 (24), pp. 335–338, 2001, [Online]. Available: https://sid.ir/paper/18285/en

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