THE EFFECT OF ISOTRETINOIN ON PLASMA HOMOCYSTEINE CONCENTRATION OF PATIENTS WITH ACNE VULGARIS

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RAHMATI ROUDSARI M.; AKBARI MOHAMMAD REZA; KAVAND S.; BAHADORI AYAD

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Title

THE EFFECT OF ISOTRETINOIN ON PLASMA HOMOCYSTEINE CONCENTRATION OF PATIENTS WITH ACNE VULGARIS

Author(s)

RAHMATI ROUDSARI M. | AKBARI MOHAMMAD REZA | KAVAND S. | BAHADORI AYAD | Issue Writer Certificate

Keywords

ISOTRETINOINQ3

HOMOCYSTEINEQ3

LIVER FUNCTION TESTQ3

SERUM LIPIDSQ4

Abstract

Background: ISOTRETINOIN (ISO) revolutionized the treatment of acne since 1980s and therafter, sever forms of acne have been treated more effectively, with less residual cosmetic or psychological damage. The use of ISOTRETINOIN is associated with significant side-effects such as mucocutaneous involvement, dyslipidemia and increased liver enzymes. The aim of study was the evaluation of HOMOCYSTEINE (Hcy) levels and the responsible vitamins for its metabolism in patients with moderate to sever acne vulgaris undergone ISO treatment.Materials and Methods: Forty-seven (n=47) patients with acne, prepared with LIVER FUNCTION TESTs, folate, vitamin B12, HOMOCYSTEINE and SERUM LIPIDS evaluations. Hcy was evaluated before (Value 1) and on the 2nd month (value 2) of treatment with ISOTRETINOIN (0.5 mg/kg/day), by HPLC methods.Results: Hcy levels (value 1: 11.8 ±5.3mmol/L vs. value 2: 13.6±7.4mmol/L; P<0.001) were statically significantly increased in patients treated with ISO. In addition, lipids and liver enzymes increased in mentioned group. However, there was no significant correlation between Hcy levels, vitamins and liver enzymes.Conclusion: Elevated Hcy levels in patients after 2 months on ISO treatment might be resulted from liver function disturbances. Folate supplementation along with frequent evaluations of Hcy serum levels are strongly reconnnened for the prevention of a premature occlusive disease.

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APA: Copy

RAHMATI ROUDSARI, M., AKBARI, MOHAMMAD REZA, KAVAND, S., & BAHADORI, AYAD. (2009). THE EFFECT OF ISOTRETINOIN ON PLASMA HOMOCYSTEINE CONCENTRATION OF PATIENTS WITH ACNE VULGARIS. RESEARCHER BULLETIN OF MEDICAL SCIENCES (PEJOUHANDEH), 13(6 (66)), 475-480. SID. https://sid.ir/paper/18300/en

Vancouver: Copy

RAHMATI ROUDSARI M., AKBARI MOHAMMAD REZA, KAVAND S., BAHADORI AYAD. THE EFFECT OF ISOTRETINOIN ON PLASMA HOMOCYSTEINE CONCENTRATION OF PATIENTS WITH ACNE VULGARIS. RESEARCHER BULLETIN OF MEDICAL SCIENCES (PEJOUHANDEH)[Internet]. 2009;13(6 (66)):475-480. Available from: https://sid.ir/paper/18300/en

IEEE: Copy

M. RAHMATI ROUDSARI, MOHAMMAD REZA AKBARI, S. KAVAND, and AYAD BAHADORI, “THE EFFECT OF ISOTRETINOIN ON PLASMA HOMOCYSTEINE CONCENTRATION OF PATIENTS WITH ACNE VULGARIS,” RESEARCHER BULLETIN OF MEDICAL SCIENCES (PEJOUHANDEH), vol. 13, no. 6 (66), pp. 475–480, 2009, [Online]. Available: https://sid.ir/paper/18300/en

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