EVALUATION OF CARDIAC INJURY BIOMARKERS IN SHEEP WITH ACUTE LACTIC ACIDOSIS

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

FARTASHVAND M.; HAJISADEGHI Y.

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: VETERINARY CLINICAL PATHOLOGY (VETERINARY JOURNAL TABRIZ) Year:2016 | Volume:10 | Issue:2 (38) Page(s): 165-171

Download Full-Text

Persian Verion

View:

2,340

Download:

Cites:

Information Journal Paper

Title

EVALUATION OF CARDIAC INJURY BIOMARKERS IN SHEEP WITH ACUTE LACTIC ACIDOSIS

Author(s)

FARTASHVAND M. | HAJISADEGHI Y. | Issue Writer Certificate

Keywords

ACUTE LACTIC ACIDOSISQ1

CARDIAC DAMAGEQ1

CTNIQ2

CK-MBQ1

Abstract

Rumen lactic acidosis is a metabolic disorder which develops in ruminants that have ingested large amounts of unaccustomed feeds rich in ruminally fermentable carbohydrates. In this study we investigated the relationship between serum lactate levels and ruminal fluid pH with changes of CARDIAC DAMAGE biomarkers in serum in 200 sheep with acute ruminal lactic acidosis (ARLA) and 50 healthy ones. After confirmation of ARLA through clinical examination and ruminal fluid pH5.5, venous blood samples were collected and special analysis carried out on serum samples. According to the findings ruminal fluid pH in diseased and healthy sheep were 5.28 ± 0.2 and 6.93±0.3, respectively. Serum lactate level in sheep with ARLA was significantly higher than normal sheep. (p=0.000). CTNI levels was 0.684±0.03 ng/ml in sheep with ARLA, which was significantly (p=0.000) higher than healthy sheep (0.005±0.00 ng/ml). Other cardiac biomarkers were increased in diseased group, however only elevation of serum activities of AST and CK-MB were statistically significant (p=0.002 and p=0.007 respectively). Although serum LDH activity in diseased group was higher than control group; but this difference was statistically non-significant (p=0.063). There was significant negative correlation between ruminal fluid pH with CTNI concentrations (p=0.004; r=–0.850); so that highest levels of CTNI (2.28 to 3.06 ng/ml) were recorded in three sheep with ruminal fluid pH<4.5. Despite medical treatments, all of these sheep died. Increase of serum activities of cardiac enzymes and CTNI concentration in sheep affected by ARLA without cardiac disease may be due to indirect effects of acidosis on cardiac muscle mediated by metabolic changes, tachycardia and increasing of sympathetic tone. In conclusion, the significant correlations observed between serum lactate level and cardiac biomarkers could be due to alterations in cardiac muscle function brought about by this metabolic disease.

Cites

No record.

References

THE EFFECTS OF EXPERIMENTALLY INDUCED LACTIC ACIDOSIS ON SERUM GLUCOSE, BUN, SERUM ELECTROLYTE (K, NA, P, CA), HAEMATOCRIT, RUMEN PH, RUMEN MICROTLORA AND PATHOLOGICAL CHANGES OF RUMINAL EPITHELIUM IN LORI SHEEP

Cite

APA: Copy

FARTASHVAND, M., & HAJISADEGHI, Y.. (2016). EVALUATION OF CARDIAC INJURY BIOMARKERS IN SHEEP WITH ACUTE LACTIC ACIDOSIS. VETERINARY CLINICAL PATHOLOGY (VETERINARY JOURNAL TABRIZ), 10(2 (38)), 165-171. SID. https://sid.ir/paper/183009/en

Vancouver: Copy

FARTASHVAND M., HAJISADEGHI Y.. EVALUATION OF CARDIAC INJURY BIOMARKERS IN SHEEP WITH ACUTE LACTIC ACIDOSIS. VETERINARY CLINICAL PATHOLOGY (VETERINARY JOURNAL TABRIZ)[Internet]. 2016;10(2 (38)):165-171. Available from: https://sid.ir/paper/183009/en

IEEE: Copy

M. FARTASHVAND, and Y. HAJISADEGHI, “EVALUATION OF CARDIAC INJURY BIOMARKERS IN SHEEP WITH ACUTE LACTIC ACIDOSIS,” VETERINARY CLINICAL PATHOLOGY (VETERINARY JOURNAL TABRIZ), vol. 10, no. 2 (38), pp. 165–171, 2016, [Online]. Available: https://sid.ir/paper/183009/en

Related Journal Papers