The role of vitamin A in preventing fetal injuries caused by injection of Escherichia coli lipopolysaccharide in the rat

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Delkhosh a.; DELASHOUB M.; KHAKPOUR M.

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Journal: VETERINARY CLINICAL PATHOLOGY (VETERINARY JOURNAL TABRIZ) Year:2019 | Volume:13 | Issue:1 (49) Page(s): 77-90

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Title

The role of vitamin A in preventing fetal injuries caused by injection of Escherichia coli lipopolysaccharide in the rat

Author(s)

Delkhosh a. | DELASHOUB M. | KHAKPOUR M. | Issue Writer Certificate

Keywords

Vitamin AQ1

LipopolysaccharideQ2

Escherichia coliQ1

Fetal injuryQ1

AntioxidantQ1

Abstract

Lipopolysaccharides (LPS) induce adverse fetal development including intrauterine growth retardation (IUGR), intrauterine fetal death (IUFD), embryonic resorption and preterm delivery which are all related to LPS-induced oxidative stress. This study aimed to investigate the protective role of Vitamin A against LPS induced fetal defects in the rat. In this study, 48 pregnant female rats were divided into 4 groups. On days 15 to 17 of pregnancy, 75 mg/kg of E. coli LPS was injected intraperitoneally in groups 1 and 2 the second and third groups received 100 mg/kg of Vitamin A intramuscularly a week before injection of LPS. The fourth group was the control group and placebo was injected to simulate injection stress. On the 18th day, all rats were euthanized. The number of live and dead fetuses and resorption sites was counted. Live fetuses in each litter were weighed, crown-rump and tail lengths measured and skeletal development was evaluated. In addition, maternal liver, placenta, and fetal liver samples were excised for measurement of MDA and GSH contents. The results showed that administration of LPS significantly increased fetal mortality, decreased fetal weight and crown-rump and tail lengths of live fetuses and retarded skeletal ossification in caudal vertebrae, anterior and posterior phalanges and supraoccipital bone. Our study showed that co-treatment of Vitamin A and LPS could decrease LPS induced defects and improve injuries indicating the preventive effects of Vitamin A against LPS induced injuries during fetal development.

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APA: Copy

Delkhosh, a., DELASHOUB, M., & KHAKPOUR, M.. (2019). The role of vitamin A in preventing fetal injuries caused by injection of Escherichia coli lipopolysaccharide in the rat. VETERINARY CLINICAL PATHOLOGY (VETERINARY JOURNAL TABRIZ), 13(1 (49) ), 77-90. SID. https://sid.ir/paper/183022/en

Vancouver: Copy

Delkhosh a., DELASHOUB M., KHAKPOUR M.. The role of vitamin A in preventing fetal injuries caused by injection of Escherichia coli lipopolysaccharide in the rat. VETERINARY CLINICAL PATHOLOGY (VETERINARY JOURNAL TABRIZ)[Internet]. 2019;13(1 (49) ):77-90. Available from: https://sid.ir/paper/183022/en

IEEE: Copy

a. Delkhosh, M. DELASHOUB, and M. KHAKPOUR, “The role of vitamin A in preventing fetal injuries caused by injection of Escherichia coli lipopolysaccharide in the rat,” VETERINARY CLINICAL PATHOLOGY (VETERINARY JOURNAL TABRIZ), vol. 13, no. 1 (49) , pp. 77–90, 2019, [Online]. Available: https://sid.ir/paper/183022/en

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