STUDY OF ANTIFUNGAL DRUG (GRISEOFULVIN) EFFECT ON THE EXPRESSION OF CHITIN SYNTHASE IN TRICHOPHYTON RUBRUM

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

VAFAEI M.; REZAIE S.; NOORBAKHSH F.; GHADERY H.; MOTAVAZE K.; EMAMI M.; SAFARI M.R.

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: BIOLOGICAL SCIENCES (DANISH-I ZISTI-I IRAN) Year:2008 | Volume:3 | Issue:2 Page(s): 1-8

Download Full-Text

Persian Verion

View:

1,418

Download:

Cites:

Information Journal Paper

Title

STUDY OF ANTIFUNGAL DRUG (GRISEOFULVIN) EFFECT ON THE EXPRESSION OF CHITIN SYNTHASE IN TRICHOPHYTON RUBRUM

Author(s)

Keywords

DERMATOPHYTEQ2

TRICHOPHYTON RUBRUMQ3

CHITIN SYNTHASEQ3

GRISEOFULVINQ3

MULTIPLEX- PCRQ3

Abstract

Trichophyton rubrum is one of the anthropophagic DERMATOPHYTEs with worldwide distribution. This fungus is a common causative agent of tinea cruris, tinea corporis, tinea manuum and tinea pedis. Current laboratory methods are main methods to study this fungus, even though taking a long time. In spite of many studies in the field of cellular and molecular biology, molecular investigations on DERMATOPHYTE fungi are very few and limited. Nowadays resistance had been seen against antifungal drugs. Producing of new drugs or accession to suitable efficacy of existing drugs require more study and finding in the field of molecular biology. In this fundamental study, serial dilutions of GRISEOFULVIN with fungal growth were prepared and compared with control sample that was not affected by any drugs. RNAs were then extracted. Afterwards Multiplex-PCR was performed simultaneously for CHITIN SYNTHASE and mg/ml beta actin genes in each one of three samples.Microscopically, rate of shortened and twisted mycelia in 0.02 dilution of GRISEOFULVIN was much higher than in 0.006 mg/ml dilutions. But regarding the gene expression of chitin synthesis, there was no difference between the control sample and ones affected by GRISEOFULVIN.

Cites

No record.

References

بررسی تاثیر داروی گریزئوفولوین بر روی بیان ژن ATPase - subunit G در قارچ درماتوفیت ترایکوفایتون روبروم

Cite

APA: Copy

VAFAEI, M., REZAIE, S., NOORBAKHSH, F., GHADERY, H., MOTAVAZE, K., EMAMI, M., & SAFARI, M.R.. (2008). STUDY OF ANTIFUNGAL DRUG (GRISEOFULVIN) EFFECT ON THE EXPRESSION OF CHITIN SYNTHASE IN TRICHOPHYTON RUBRUM. BIOLOGICAL SCIENCES (DANISH-I ZISTI-I IRAN), 3(2), 1-8. SID. https://sid.ir/paper/183710/en

Vancouver: Copy

VAFAEI M., REZAIE S., NOORBAKHSH F., GHADERY H., MOTAVAZE K., EMAMI M., SAFARI M.R.. STUDY OF ANTIFUNGAL DRUG (GRISEOFULVIN) EFFECT ON THE EXPRESSION OF CHITIN SYNTHASE IN TRICHOPHYTON RUBRUM. BIOLOGICAL SCIENCES (DANISH-I ZISTI-I IRAN)[Internet]. 2008;3(2):1-8. Available from: https://sid.ir/paper/183710/en

IEEE: Copy

M. VAFAEI, S. REZAIE, F. NOORBAKHSH, H. GHADERY, K. MOTAVAZE, M. EMAMI, and M.R. SAFARI, “STUDY OF ANTIFUNGAL DRUG (GRISEOFULVIN) EFFECT ON THE EXPRESSION OF CHITIN SYNTHASE IN TRICHOPHYTON RUBRUM,” BIOLOGICAL SCIENCES (DANISH-I ZISTI-I IRAN), vol. 3, no. 2, pp. 1–8, 2008, [Online]. Available: https://sid.ir/paper/183710/en

Related Journal Papers